MicroRNAs Involved in the Lipid Metabolism and Their Possible
Implications for Atherosclerosis Development and Treatment

J 2014

MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment

NOVÁK, Jan, Julie BIENERTOVÁ VAŠKŮ, Tomáš KÁRA and Miroslav NOVÁK

Basic information

Original name

MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment

Authors

NOVÁK, Jan (203 Czech Republic, guarantor, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Tomáš KÁRA (203 Czech Republic) and Miroslav NOVÁK (203 Czech Republic)

Edition

Mediators of Inflammation, New York, Hindawi Publishing Corporation, 2014, 0962-9351

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.236

RIV identification code

RIV/00216224:14110/14:00075532

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2014/275867

UT WoS

000335329700001

Keywords in English

microRNA; lipid metabolism; atherosclerosis; circulating microRNA

Abstract

V originále

Hyperlipidemia is a well-accepted risk factor in the development of atherosclerosis. MicroRNAs (miRNAs), a novel class of posttranscriptional regulators of gene expression, are involved in a variety of biological and pathological processes, including the regulation of the lipid metabolism and atherosclerosis. As our knowledge of miRNAs expands, a new class of "circulating miRNAs" has recently been described. It includes miRNAs which may be found in various bodily fluids packaged in microvesicles/exosomes, or bound to specific transporting proteins. High-density lipoprotein (HDL) particles have been identified as one such carrier. As this class of miRNAs likely plays a role in intercellular communication, it may also contribute to the atherosclerosis development and progression. This review aims to provide a comprehensive explanation of the roles of distinct miRNAs involved in the regulation of the lipid metabolism. These microRNAs seem to be promising therapeutic agents, as documented in rodents and African green monkeys. The second part of the review focuses on circulating miRNAs and their involvement in the atherosclerosis, especially as their levels have been described as altered in patients with dyslipidemia/hyperlipidemia. Special emphasis is placed on miRNAs transported in a complex with HDL particles and on those which may be considered potential atherosclerosis biomarkers.

Links

MUNI/A/0957/2013, interní kód MU

Name: Studium kardiovaskulárních regulací ve zdraví i nemoci (Acronym: SKAREZNEM)

Investor: Masaryk University, Category A

Citovat

NOVÁK, Jan, Julie BIENERTOVÁ VAŠKŮ, Tomáš KÁRA and Miroslav NOVÁK. MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment. Mediators of Inflammation. New York: Hindawi Publishing Corporation, 2014, vol. 2014, No 275867, p. 1-14. ISSN 0962-9351. Available from: https://dx.doi.org/10.1155/2014/275867.

@article{1183299,
   author = {Novák, Jan and Bienertová Vašků, Julie and Kára, Tomáš and Novák, Miroslav},
   article_location = {New York},
   article_number = {275867},
   doi = {http://dx.doi.org/10.1155/2014/275867},
   keywords = {microRNA; lipid metabolism; atherosclerosis; circulating microRNA},
   language = {eng},
   issn = {0962-9351},
   journal = {Mediators of Inflammation},
   title = {MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment},
   url = {http://www.hindawi.com/journals/mi/2014/275867/},
   volume = {2014},
   year = {2014}
}

TY  - JOUR
ID  - 1183299
AU  - Novák, Jan - Bienertová Vašků, Julie - Kára, Tomáš - Novák, Miroslav
PY  - 2014
TI  - MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment
JF  - Mediators of Inflammation
VL  - 2014
IS  - 275867
SP  - 1-14
EP  - 1-14
PB  - Hindawi Publishing Corporation
SN  - 09629351
KW  - microRNA
KW  - lipid metabolism
KW  - atherosclerosis
KW  - circulating microRNA
UR  - http://www.hindawi.com/journals/mi/2014/275867/
N2  - Hyperlipidemia is a well-accepted risk factor in the development of atherosclerosis. MicroRNAs (miRNAs), a novel class of posttranscriptional regulators of gene expression, are involved in a variety of biological and pathological processes, including the regulation of the lipid metabolism and atherosclerosis. As our knowledge of miRNAs expands, a new class of "circulating miRNAs" has recently been described. It includes miRNAs which may be found in various bodily fluids packaged in microvesicles/exosomes, or bound to specific transporting proteins. High-density lipoprotein (HDL) particles have been identified as one such carrier. As this class of miRNAs likely plays a role in intercellular communication, it may also contribute to the atherosclerosis development and progression. This review aims to provide a comprehensive explanation of the roles of distinct miRNAs involved in the regulation of the lipid metabolism. These microRNAs seem to be promising therapeutic agents, as documented in rodents and African green monkeys. The second part of the review focuses on circulating miRNAs and their involvement in the atherosclerosis, especially as their levels have been described as altered in patients with dyslipidemia/hyperlipidemia. Special emphasis is placed on miRNAs transported in a complex with HDL particles and on those which may be considered potential atherosclerosis biomarkers.
ER  -

NOVÁK, Jan, Julie BIENERTOVÁ VAŠKŮ, Tomáš KÁRA and Miroslav NOVÁK. MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment. \textit{Mediators of Inflammation}. New York: Hindawi Publishing Corporation, 2014, vol.~2014, No~275867, p.~1-14. ISSN~0962-9351. Available from: https://dx.doi.org/10.1155/2014/275867.

Detailed Information on Publication Record