| LEUCHT, Katharina, Anne FISCHBECK, Michaela CAJ, Gerhard LIEBISCH, Eva HARTLIEB, Petr BENEŠ, Michael FRIED, Hans Ulrich HUMPF, Gerhard ROGLER a Martin HAUSMANN. Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells. Molecular Nutrition & Food Research. Hoboken (USA): Wiley-Blackwell, 2014, roč. 58, č. 4, s. 782-798. ISSN 1613-4125. Dostupné z: https://dx.doi.org/10.1002/mnfr.201300369. |
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@article{1184015,
author = {Leucht, Katharina and Fischbeck, Anne and Caj, Michaela and Liebisch, Gerhard and Hartlieb, Eva and Beneš, Petr and Fried, Michael and Humpf, Hans Ulrich and Rogler, Gerhard and Hausmann, Martin},
article_location = {Hoboken (USA)},
article_number = {4},
doi = {http://dx.doi.org/10.1002/mnfr.201300369},
keywords = {Apoptosis; BID; Cathepsin D; Phosphatidylcholine; Sphingomyelin},
language = {eng},
issn = {1613-4125},
journal = {Molecular Nutrition & Food Research},
title = {Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells},
url = {http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201300369/abstract},
volume = {58},
year = {2014}
}
TY - JOUR
ID - 1184015
AU - Leucht, Katharina - Fischbeck, Anne - Caj, Michaela - Liebisch, Gerhard - Hartlieb, Eva - Beneš, Petr - Fried, Michael - Humpf, Hans Ulrich - Rogler, Gerhard - Hausmann, Martin
PY - 2014
TI - Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells
JF - Molecular Nutrition & Food Research
VL - 58
IS - 4
SP - 782-798
EP - 782-798
PB - Wiley-Blackwell
SN - 16134125
KW - Apoptosis
KW - BID
KW - Cathepsin D
KW - Phosphatidylcholine
KW - Sphingomyelin
UR - http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201300369/abstract
L2 - http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201300369/abstract
N2 - The major alimentary sources for the plasma membrane lipid sphingomyelin (SM) are dairy products, eggs, and meat.We recently reported that the SM metabolite ceramide induces cathepsin D mediated apoptosis in murine intestinal epithelial cells (IECs) and increases inflammation in acute colitis. We investigated the impact of SM and phosphatidylcholine on apoptosis in human IECs and point out BH3-interacting death agonist (BID) as link between cathepsin D and apoptosis. HT–29 and isolated human IECs were stimulated with SM or phosphatidylcholine. SM treatment resulted in increased apoptosis. Phosphatidylcholine showed contrary effects. Western revealed higher amounts of cathepsin D and BID activation upon lipid stimulation. Western blotting revealed BID activation through SM in both an induced and a spontaneous mouse model of colitis. Dietary phospholipids may induce or abolish apoptosis in IECs and seem to play a role in the pathogenesis of inflammatory bowel diseases. This nutritional factor might be considered when evaluating the pathogenesis of inflammatory bowel diseases. Effects of SMase- and SM treatment on inflammation in dextran sulfate sodium induced animal models of colitis and in vitro experiments are discussed as controversial. Variable sources of SM, feeding techniques, and mouse strains might play a role.
ER -
LEUCHT, Katharina, Anne FISCHBECK, Michaela CAJ, Gerhard LIEBISCH, Eva HARTLIEB, Petr BENEŠ, Michael FRIED, Hans Ulrich HUMPF, Gerhard ROGLER a Martin HAUSMANN. Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells. \textit{Molecular Nutrition \&{} Food Research}. Hoboken (USA): Wiley-Blackwell, 2014, roč.~58, č.~4, s.~782-798. ISSN~1613-4125. Dostupné z: https://dx.doi.org/10.1002/mnfr.201300369.
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