| HOFMANOVÁ, Jiřina, Nicol STRAKOVÁ, Alena HYRŠLOVÁ VACULOVÁ, Zuzana TYLICHOVÁ, Barbora ŠAFAŘÍKOVÁ, Belma SKENDER and Alois KOZUBÍK. Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer. Mediators of Inflammation. Hindawi Publishing Corporation, 2014, vol. 2014, No 2014, p. "nestrankovano", 17 pp. ISSN 0962-9351. Available from: https://dx.doi.org/10.1155/2014/848632. |
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@article{1184670,
author = {Hofmanová, Jiřina and Straková, Nicol and Hyršlová Vaculová, Alena and Tylichová, Zuzana and Šafaříková, Barbora and Skender, Belma and Kozubík, Alois},
article_number = {2014},
doi = {http://dx.doi.org/10.1155/2014/848632},
keywords = {NF-KAPPA-B; TRAIL-INDUCED APOPTOSIS; RECEPTOR-MEDIATED APOPTOSIS},
language = {eng},
issn = {0962-9351},
journal = {Mediators of Inflammation},
title = {Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer},
volume = {2014},
year = {2014}
}
TY - JOUR
ID - 1184670
AU - Hofmanová, Jiřina - Straková, Nicol - Hyršlová Vaculová, Alena - Tylichová, Zuzana - Šafaříková, Barbora - Skender, Belma - Kozubík, Alois
PY - 2014
TI - Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
JF - Mediators of Inflammation
VL - 2014
IS - 2014
SP - "nestrankovano"
EP - "nestrankovano"
PB - Hindawi Publishing Corporation
SN - 09629351
KW - NF-KAPPA-B
KW - TRAIL-INDUCED APOPTOSIS
KW - RECEPTOR-MEDIATED APOPTOSIS
N2 - Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-alpha,TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NF kappa B activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development. We summarised recent knowledge about the cellular and molecular mechanisms involved in such effects and outcomes for intestinal cell behaviour and pathologies. Finally, the possible application for the prevention and therapy of colon inflammation and cancer is also outlined.
ER -
HOFMANOVÁ, Jiřina, Nicol STRAKOVÁ, Alena HYRŠLOVÁ VACULOVÁ, Zuzana TYLICHOVÁ, Barbora ŠAFAŘÍKOVÁ, Belma SKENDER and Alois KOZUBÍK. Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer. \textit{Mediators of Inflammation}. Hindawi Publishing Corporation, 2014, vol.~2014, No~2014, p.~''nestrankovano'', 17 pp. ISSN~0962-9351. Available from: https://dx.doi.org/10.1155/2014/848632.
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