Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon ...
HOFMANOVÁ, Jiřina, Nicol STRAKOVÁ, Alena HYRŠLOVÁ VACULOVÁ, Zuzana TYLICHOVÁ, Barbora ŠAFAŘÍKOVÁ, Belma SKENDER and Alois KOZUBÍK. Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer. Mediators of Inflammation. Hindawi Publishing Corporation, 2014, vol. 2014, No 2014, p. "nestrankovano", 17 pp. ISSN 0962-9351. Available from: https://dx.doi.org/10.1155/2014/848632. |
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Original name | Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer |
Authors | HOFMANOVÁ, Jiřina (203 Czech Republic), Nicol STRAKOVÁ (203 Czech Republic), Alena HYRŠLOVÁ VACULOVÁ (203 Czech Republic), Zuzana TYLICHOVÁ (203 Czech Republic, belonging to the institution), Barbora ŠAFAŘÍKOVÁ (203 Czech Republic, belonging to the institution), Belma SKENDER (70 Bosnia and Herzegovina) and Alois KOZUBÍK (203 Czech Republic, belonging to the institution). |
Edition | Mediators of Inflammation, Hindawi Publishing Corporation, 2014, 0962-9351. |
Other information | |
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Original language | English |
Type of outcome | Article in a journal |
Field of Study | 30105 Physiology |
Country of publisher | United States of America |
Confidentiality degree | is not subject to a state or trade secret |
Impact factor | Impact factor: 3.236 |
RIV identification code | RIV/00216224:14310/14:00082028 |
Organization unit | Faculty of Science |
Doi | http://dx.doi.org/10.1155/2014/848632 |
UT WoS | 000335742300001 |
Keywords in English | NF-KAPPA-B; TRAIL-INDUCED APOPTOSIS; RECEPTOR-MEDIATED APOPTOSIS |
Tags | AKR, rivok |
Changed by | Changed by: Ing. Andrea Mikešková, učo 137293. Changed: 26/4/2016 15:58. |
Abstract |
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Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-alpha,TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NF kappa B activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development. We summarised recent knowledge about the cellular and molecular mechanisms involved in such effects and outcomes for intestinal cell behaviour and pathologies. Finally, the possible application for the prevention and therapy of colon inflammation and cancer is also outlined. |
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