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@article{1185415,
author = {Hofer, Michal and Pospíšil, Milan and Dušek, Ladislav and Hoferová, Zuzana and Komurkova, Denisa},
article_location = {New York},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s00411-013-0500-y},
keywords = {Ionizing radiation; Acute radiation disease; Survival; Adenosine A(3) receptor agonist; Cyclooxygenase-2 inhibitor},
language = {eng},
issn = {0301-634X},
journal = {Radiation and Environmental Biophysics},
title = {Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice},
volume = {53},
year = {2014}
}
TY - JOUR
ID - 1185415
AU - Hofer, Michal - Pospíšil, Milan - Dušek, Ladislav - Hoferová, Zuzana - Komurkova, Denisa
PY - 2014
TI - Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice
JF - Radiation and Environmental Biophysics
VL - 53
IS - 1
SP - 211-215
EP - 211-215
PB - Springer-Verlag
SN - 0301634X
KW - Ionizing radiation
KW - Acute radiation disease
KW - Survival
KW - Adenosine A(3) receptor agonist
KW - Cyclooxygenase-2 inhibitor
N2 - There exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal gamma-ray dose of 8.5 Gy and treated with single doses of an adenosine A(3) receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice. Combined administration of IB-MECA and meloxicam was found to be the only treatment statistically enhancing the parameter of CPS and to lead to the most expressive increase in MST of the experimental mice. The findings add new knowledge on the action of an adenosine A(3) receptor agonist and a COX-2 inhibitor in an irradiated mammalian organism and suggest the potential of both the investigated drugs in the treatment of the acute radiation damage.
ER -
HOFER, Michal, Milan POSPÍŠIL, Ladislav DUŠEK, Zuzana HOFEROVÁ a Denisa KOMURKOVA. Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice. \textit{Radiation and Environmental Biophysics}. New York: Springer-Verlag, roč.~53, č.~1, s.~211-215. ISSN~0301-634X. doi:10.1007/s00411-013-0500-y. 2014.
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