Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor
of cyclooxygenase-2, meloxicam, given alone or in a combination
early after total body irradiation enhance survival of
gamma-irradiated mice

J 2014

Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice

HOFER, Michal, Milan POSPÍŠIL, Ladislav DUŠEK, Zuzana HOFEROVÁ, Denisa KOMURKOVA et. al.

Basic information

Original name

Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice

Authors

HOFER, Michal (203 Czech Republic), Milan POSPÍŠIL (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, guarantor, belonging to the institution), Zuzana HOFEROVÁ (203 Czech Republic) and Denisa KOMURKOVA (203 Czech Republic)

Edition

Radiation and Environmental Biophysics, New York, Springer-Verlag, 2014, 0301-634X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10610 Biophysics

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.528

RIV identification code

RIV/00216224:14110/14:00073672

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00411-013-0500-y

UT WoS

000331977300018

Keywords in English

Ionizing radiation; Acute radiation disease; Survival; Adenosine A(3) receptor agonist; Cyclooxygenase-2 inhibitor

Abstract

V originále

There exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal gamma-ray dose of 8.5 Gy and treated with single doses of an adenosine A(3) receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice. Combined administration of IB-MECA and meloxicam was found to be the only treatment statistically enhancing the parameter of CPS and to lead to the most expressive increase in MST of the experimental mice. The findings add new knowledge on the action of an adenosine A(3) receptor agonist and a COX-2 inhibitor in an irradiated mammalian organism and suggest the potential of both the investigated drugs in the treatment of the acute radiation damage.

Links

GA305/08/0158, research and development project

Name: Aktivace adenosinových receptorů kombinovaná s inhibicí cyklooxygenázy v modulaci zářením vyvolaného poškození kostní dřeně

Investor: Czech Science Foundation, Activation of adenosine receptors combined with cyclooxygenase inhibition in modulation of radiation-induced myelosuppression

Citovat

HOFER, Michal, Milan POSPÍŠIL, Ladislav DUŠEK, Zuzana HOFEROVÁ and Denisa KOMURKOVA. Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice. Radiation and Environmental Biophysics. New York: Springer-Verlag, 2014, vol. 53, No 1, p. 211-215. ISSN 0301-634X. Available from: https://dx.doi.org/10.1007/s00411-013-0500-y.

@article{1185415,
   author = {Hofer, Michal and Pospíšil, Milan and Dušek, Ladislav and Hoferová, Zuzana and Komurkova, Denisa},
   article_location = {New York},
   article_number = {1},
   doi = {http://dx.doi.org/10.1007/s00411-013-0500-y},
   keywords = {Ionizing radiation; Acute radiation disease; Survival; Adenosine A(3) receptor agonist; Cyclooxygenase-2 inhibitor},
   language = {eng},
   issn = {0301-634X},
   journal = {Radiation and Environmental Biophysics},
   title = {Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice},
   volume = {53},
   year = {2014}
}

TY  - JOUR
ID  - 1185415
AU  - Hofer, Michal - Pospíšil, Milan - Dušek, Ladislav - Hoferová, Zuzana - Komurkova, Denisa
PY  - 2014
TI  - Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice
JF  - Radiation and Environmental Biophysics
VL  - 53
IS  - 1
SP  - 211-215
EP  - 211-215
PB  - Springer-Verlag
SN  - 0301634X
KW  - Ionizing radiation
KW  - Acute radiation disease
KW  - Survival
KW  - Adenosine A(3) receptor agonist
KW  - Cyclooxygenase-2 inhibitor
N2  - There exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal gamma-ray dose of 8.5 Gy and treated with single doses of an adenosine A(3) receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice. Combined administration of IB-MECA and meloxicam was found to be the only treatment statistically enhancing the parameter of CPS and to lead to the most expressive increase in MST of the experimental mice. The findings add new knowledge on the action of an adenosine A(3) receptor agonist and a COX-2 inhibitor in an irradiated mammalian organism and suggest the potential of both the investigated drugs in the treatment of the acute radiation damage.
ER  -

HOFER, Michal, Milan POSPÍŠIL, Ladislav DUŠEK, Zuzana HOFEROVÁ and Denisa KOMURKOVA. Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice. \textit{Radiation and Environmental Biophysics}. New York: Springer-Verlag, 2014, vol.~53, No~1, p.~211-215. ISSN~0301-634X. Available from: https://dx.doi.org/10.1007/s00411-013-0500-y.

Detailed Information on Publication Record