SCHINKOVITZ, Andreas, Avinash Kaur KANG, Ernst URBAN, Martin ZEHL, Gabriela PÁCHNIKOVÁ, Yuehong WANG, Nadine KRETSCHMER, Iva SLANINOVÁ, Guido F. PAULI, Scott G. FRANZBLAU, Georg KRUPITZA, Rudolf BAUER and Brigitte KOPP. Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation. Journal of Natural Products. Washington: American Chemical Society, 2014, vol. 77, No 4, p. 1069-1073. ISSN 0163-3864. Available from: https://dx.doi.org/10.1021/np4008574. |
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@article{1185588, author = {Schinkovitz, Andreas and Kang, Avinash Kaur and Urban, Ernst and Zehl, Martin and Páchniková, Gabriela and Wang, Yuehong and Kretschmer, Nadine and Slaninová, Iva and Pauli, Guido F. and Franzblau, Scott G. and Krupitza, Georg and Bauer, Rudolf and Kopp, Brigitte}, article_location = {Washington}, article_number = {4}, doi = {http://dx.doi.org/10.1021/np4008574}, keywords = {USNEA-LONGISSIMA; LICHEN; ACID; PULMONARIA}, language = {eng}, issn = {0163-3864}, journal = {Journal of Natural Products}, title = {Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation}, volume = {77}, year = {2014} }
TY - JOUR ID - 1185588 AU - Schinkovitz, Andreas - Kang, Avinash Kaur - Urban, Ernst - Zehl, Martin - Páchniková, Gabriela - Wang, Yuehong - Kretschmer, Nadine - Slaninová, Iva - Pauli, Guido F. - Franzblau, Scott G. - Krupitza, Georg - Bauer, Rudolf - Kopp, Brigitte PY - 2014 TI - Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation JF - Journal of Natural Products VL - 77 IS - 4 SP - 1069-1073 EP - 1069-1073 PB - American Chemical Society SN - 01633864 KW - USNEA-LONGISSIMA KW - LICHEN KW - ACID KW - PULMONARIA N2 - Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds. ER -
SCHINKOVITZ, Andreas, Avinash Kaur KANG, Ernst URBAN, Martin ZEHL, Gabriela PÁCHNIKOVÁ, Yuehong WANG, Nadine KRETSCHMER, Iva SLANINOVÁ, Guido F. PAULI, Scott G. FRANZBLAU, Georg KRUPITZA, Rudolf BAUER and Brigitte KOPP. Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation. \textit{Journal of Natural Products}. Washington: American Chemical Society, 2014, vol.~77, No~4, p.~1069-1073. ISSN~0163-3864. Available from: https://dx.doi.org/10.1021/np4008574.
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