| SÝKOROVÁ, Petra, Jitka NOVOTNÁ, Gabriel DEMO, Eva DEJMKOVÁ, Jan KOMÁREK, Lucia HÁRONÍKOVÁ, Annabelle VARROT, Anne IMBERTY, Martina POKORNÁ and Michaela WIMMEROVÁ. New family of bacterial lectins with seven bladed beta propeller fold. In Krystalografická společnost, Struktura 2014. 2014. ISSN 1805-4382. |
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@proceedings{1185612,
author = {Sýkorová, Petra and Novotná, Jitka and Demo, Gabriel and Dejmková, Eva and Komárek, Jan and Hároníková, Lucia and Varrot, Annabelle and Imberty, Anne and Pokorná, Martina and Wimmerová, Michaela},
booktitle = {Krystalografická společnost, Struktura 2014},
keywords = {lectin structure bacteria saccharide},
language = {eng},
title = {New family of bacterial lectins with seven bladed beta propeller fold},
year = {2014}
}
TY - CONF
ID - 1185612
AU - Sýkorová, Petra - Novotná, Jitka - Demo, Gabriel - Dejmková, Eva - Komárek, Jan - Hároníková, Lucia - Varrot, Annabelle - Imberty, Anne - Pokorná, Martina - Wimmerová, Michaela
PY - 2014
TI - New family of bacterial lectins with seven bladed beta propeller fold
KW - lectin structure bacteria saccharide
N2 - The crystal structures of BP39L and CV39L were determined based on a new class of lanthanide complexes for heavy atom derivatization (SAD experiment). The BP39L lectin crystallized in I222 space group and CV39L in P212121. The structures of both lectins revealed seven bladed beta propeller fold with possibly seven binding sites per monomer. The BP39L lectin was observed as a monomer and CV39L as a dimer in solution, which was confirmed also in the crystal structure. The knowledge about the structure together with sequence and structure predictions indicates that the proteins belong to an undescribed new family of lectins. The functional studies indicate the specificity of lectin BP39L towards mannose and CV39L towards fucose and galactose.
ER -
SÝKOROVÁ, Petra, Jitka NOVOTNÁ, Gabriel DEMO, Eva DEJMKOVÁ, Jan KOMÁREK, Lucia HÁRONÍKOVÁ, Annabelle VARROT, Anne IMBERTY, Martina POKORNÁ and Michaela WIMMEROVÁ. New family of bacterial lectins with seven bladed beta propeller fold. In \textit{Krystalografická společnost, Struktura 2014}. 2014. ISSN~1805-4382.
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