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@article{1186358,
author = {Legartová, Soňa and Kozubek, Stanislav and Fránek, Michal and Zdráhal, Zbyněk and Lochmanová, Gabriela and Martinet, Nadine and Bártová, Eva},
article_location = {OTTAWA},
article_number = {2},
doi = {http://dx.doi.org/10.1139/bcb-2013-0082},
keywords = {NEWLY SYNTHESIZED HISTONES; EMBRYONIC STEM-CELLS; NUCLEAR ARRANGEMENT; REPLICATION FORK; H3K9 ACETYLATION; CHROMATIN; TRANSCRIPTION; H4; COMPLEX; SITES},
language = {eng},
issn = {0829-8211},
journal = {BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE},
title = {Cell differentiation along multiple pathways accompanied by changes in histone acetylation status},
url = {http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.VQAanuFFrs4},
volume = {92},
year = {2014}
}
TY - JOUR
ID - 1186358
AU - Legartová, Soňa - Kozubek, Stanislav - Fránek, Michal - Zdráhal, Zbyněk - Lochmanová, Gabriela - Martinet, Nadine - Bártová, Eva
PY - 2014
TI - Cell differentiation along multiple pathways accompanied by changes in histone acetylation status
JF - BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
VL - 92
IS - 2
SP - 85-93
EP - 85-93
PB - CANADIAN SCIENCE PUBLISHING
SN - 08298211
KW - NEWLY SYNTHESIZED HISTONES
KW - EMBRYONIC STEM-CELLS
KW - NUCLEAR ARRANGEMENT
KW - REPLICATION FORK
KW - H3K9 ACETYLATION
KW - CHROMATIN
KW - TRANSCRIPTION
KW - H4
KW - COMPLEX
KW - SITES
UR - http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.VQAanuFFrs4
L2 - http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.VQAanuFFrs4
N2 - Post-translational modification of histones is fundamental to the regulation of basic nuclear processes and subsequent cellular events, including differentiation. In this study, we analyzed acetylated forms of histones H2A, H2B, and H4 during induced differentiation in mouse (mESCs) and human (hESCs) embryonic stem cells and during induced enterocytic differentiation of colon cancer cells in vitro. Endoderm-like differentiation of mESCs induced by retinoic acid and enterocytic differentiation induced by histone deacetylase inhibitor sodium butyrate were accompanied by increased mono-, di-, and tri-acetylation of histone H2B and a pronounced increase in di- and tri-acetylation of histone H4. In enterocytes, mono- acetylation of histone H2A also increased and tetra-acetylation of histone H4 appeared only after induction of this differentiation pathway. During differentiation of hESCs, we observed increased mono-acetylation and decreased tri-acetylation of H2B. Mono-, di-, and tri-acetylation of H4 were reduced, manifested by a significant increase in nonacetylated H4 histones. Levels of acetylated histones increased during induced differentiation in mESCs and during histone deacetylase (HDAC) inhibitor-induced enterocytic differentiation, whereas differentiation of human ESCs was associated with reduced acetylation of histones H2B and H4.
ER -
LEGARTOVÁ, Soňa, Stanislav KOZUBEK, Michal FRÁNEK, Zbyněk ZDRÁHAL, Gabriela LOCHMANOVÁ, Nadine MARTINET a Eva BÁRTOVÁ. Cell differentiation along multiple pathways accompanied by changes in histone acetylation status. \textit{BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE}. OTTAWA: CANADIAN SCIENCE PUBLISHING, roč.~92, č.~2, s.~85-93. ISSN~0829-8211. doi:10.1139/bcb-2013-0082. 2014.
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