Abnormalities in Myelination of the Superior Cerebellar
Peduncle in Patients with Schizophrenia and Deficits in
Movement Sequencing

J 2014

Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing

HÜTTLOVÁ, Jitka, Zora KIKINIS, Miloš KEŘKOVSKÝ, Sylvain BOUIX, Vu MAI-ANH et. al.

Basic information

Original name

Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing

Authors

HÜTTLOVÁ, Jitka (203 Czech Republic, belonging to the institution), Zora KIKINIS (840 United States of America), Miloš KEŘKOVSKÝ (203 Czech Republic, belonging to the institution), Sylvain BOUIX (840 United States of America), Vu MAI-ANH (840 United States of America), Nikos MAKRIS (840 United States of America), Martha SHENTON (840 United States of America) and Tomáš KAŠPÁREK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cerebellum, New York, Springer, 2014, 1473-4222

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.717

RIV identification code

RIV/00216224:14110/14:00080135

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s12311-014-0550-y

UT WoS

000338727300001

Keywords in English

Cerebellum; Cerebral peduncle; Corticospinal tracts; Diffusion tensor imaging; Psychomotor disorders; Schizophrenia

Abstract

V originále

Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficits in movement sequencing. The corticospinal tract (CST) and superior cerebellar peduncle (SCP) are fiber tracts that are involved in movement sequencing. However, the integrity of these tracts has not been evaluated in schizophrenic patients with respect to the performance of movement sequencing yet. Diffusion tensor magnetic resonance images (DT-MRI) were acquired from 24 patients with schizophrenia and 23 matched control subjects. Tractography was applied to reconstruct the CST and SCP and DT-MRI-specific parameters such as fractional anisotropy (FA) and radial diffusivity (RD) were reported. The patient group was further subdivided based on the score of sequencing of complex motor acts subscale of the Neurological Evaluation Scale into those with deficits in sequencing motor acts, the SQabn group (n = 7), and those with normal performance, the SQnorm group (n = 17). Schizophrenia patients of the SQnorm subgroup had significantly reduced FA and increased RD values in the right CST in comparison to the control group; the SQabn subgroup did not differ from the controls. However, the SQabn subgroup showed impaired integrity of the left SCP, whereas the SQnorm subgroup did not. Abnormalities in the right CST in the SQnorm and in the left SCP in SQabn groups suggest that the patients with SQabn represent subgroups with distinct deficits. Moreover, these results demonstrate the involvement of the SCP in the pathogenesis of movement sequencing in schizophrenia.

Links

CZ.1.05/1.1.00/02.0068, interní kód MU

Name: CEITEC - středoevropský technologický institut (Acronym: CEITEC)

Investor: Ministry of Education, Youth and Sports of the CR, CEITEC - Central European Institute of Technology, 1.1 European Centres of Excellence

NT13437, research and development project

Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.

Citovat

HÜTTLOVÁ, Jitka, Zora KIKINIS, Miloš KEŘKOVSKÝ, Sylvain BOUIX, Vu MAI-ANH, Nikos MAKRIS, Martha SHENTON and Tomáš KAŠPÁREK. Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing. Cerebellum. New York: Springer, 2014, vol. 13, No 4, p. 415-424. ISSN 1473-4222. Available from: https://dx.doi.org/10.1007/s12311-014-0550-y.

@article{1186382,
   author = {Hüttlová, Jitka and Kikinis, Zora and Keřkovský, Miloš and Bouix, Sylvain and MaiandAnh, Vu and Makris, Nikos and Shenton, Martha and Kašpárek, Tomáš},
   article_location = {New York},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s12311-014-0550-y},
   keywords = {Cerebellum; Cerebral peduncle; Corticospinal tracts; Diffusion tensor imaging; Psychomotor disorders; Schizophrenia},
   language = {eng},
   issn = {1473-4222},
   journal = {Cerebellum},
   title = {Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing},
   volume = {13},
   year = {2014}
}

TY  - JOUR
ID  - 1186382
AU  - Hüttlová, Jitka - Kikinis, Zora - Keřkovský, Miloš - Bouix, Sylvain - Mai-Anh, Vu - Makris, Nikos - Shenton, Martha - Kašpárek, Tomáš
PY  - 2014
TI  - Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing
JF  - Cerebellum
VL  - 13
IS  - 4
SP  - 415-424
EP  - 415-424
PB  - Springer
SN  - 14734222
KW  - Cerebellum
KW  - Cerebral peduncle
KW  - Corticospinal tracts
KW  - Diffusion tensor imaging
KW  - Psychomotor disorders
KW  - Schizophrenia
N2  - Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficits in movement sequencing. The corticospinal tract (CST) and superior cerebellar peduncle (SCP) are fiber tracts that are involved in movement sequencing. However, the integrity of these tracts has not been evaluated in schizophrenic patients with respect to the performance of movement sequencing yet. Diffusion tensor magnetic resonance images (DT-MRI) were acquired from 24 patients with schizophrenia and 23 matched control subjects. Tractography was applied to reconstruct the CST and SCP and DT-MRI-specific parameters such as fractional anisotropy (FA) and radial diffusivity (RD) were reported. The patient group was further subdivided based on the score of sequencing of complex motor acts subscale of the Neurological Evaluation Scale into those with deficits in sequencing motor acts, the SQabn group (n = 7), and those with normal performance, the SQnorm group (n = 17). Schizophrenia patients of the SQnorm subgroup had significantly reduced FA and increased RD values in the right CST in comparison to the control group; the SQabn subgroup did not differ from the controls. However, the SQabn subgroup showed impaired integrity of the left SCP, whereas the SQnorm subgroup did not. Abnormalities in the right CST in the SQnorm and in the left SCP in SQabn groups suggest that the patients with SQabn represent subgroups with distinct deficits. Moreover, these results demonstrate the involvement of the SCP in the pathogenesis of movement sequencing in schizophrenia.
ER  -

HÜTTLOVÁ, Jitka, Zora KIKINIS, Miloš KEŘKOVSKÝ, Sylvain BOUIX, Vu MAI-ANH, Nikos MAKRIS, Martha SHENTON and Tomáš KAŠPÁREK. Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing. \textit{Cerebellum}. New York: Springer, 2014, vol.~13, No~4, p.~415-424. ISSN~1473-4222. Available from: https://dx.doi.org/10.1007/s12311-014-0550-y.

Detailed Information on Publication Record