Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing

HÜTTLOVÁ, Jitka, Zora KIKINIS, Miloš KEŘKOVSKÝ, Sylvain BOUIX, Vu MAI-ANH, Nikos MAKRIS, Martha SHENTON and Tomáš KAŠPÁREK. Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing. Cerebellum. New York: Springer, 2014, vol. 13, No 4, p. 415-424. ISSN 1473-4222. Available from: https://dx.doi.org/10.1007/s12311-014-0550-y.

Basic information

• Original name: Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing
• Authors: HÜTTLOVÁ, Jitka (203 Czech Republic, belonging to the institution), Zora KIKINIS (840 United States of America), Miloš KEŘKOVSKÝ (203 Czech Republic, belonging to the institution), Sylvain BOUIX (840 United States of America), Vu MAI-ANH (840 United States of America), Nikos MAKRIS (840 United States of America), Martha SHENTON (840 United States of America) and Tomáš KAŠPÁREK (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Cerebellum, New York, Springer, 2014, 1473-4222.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.717
• RIV identification code: RIV/00216224:14110/14:00080135
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s12311-014-0550-y
• UT WoS: 000338727300001
• Keywords in English: Cerebellum; Cerebral peduncle; Corticospinal tracts; Diffusion tensor imaging; Psychomotor disorders; Schizophrenia
• Tags: EL OK
• Tags: International impact, Reviewed

Abstract

Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficits in movement sequencing. The corticospinal tract (CST) and superior cerebellar peduncle (SCP) are fiber tracts that are involved in movement sequencing. However, the integrity of these tracts has not been evaluated in schizophrenic patients with respect to the performance of movement sequencing yet. Diffusion tensor magnetic resonance images (DT-MRI) were acquired from 24 patients with schizophrenia and 23 matched control subjects. Tractography was applied to reconstruct the CST and SCP and DT-MRI-specific parameters such as fractional anisotropy (FA) and radial diffusivity (RD) were reported. The patient group was further subdivided based on the score of sequencing of complex motor acts subscale of the Neurological Evaluation Scale into those with deficits in sequencing motor acts, the SQabn group (n = 7), and those with normal performance, the SQnorm group (n = 17). Schizophrenia patients of the SQnorm subgroup had significantly reduced FA and increased RD values in the right CST in comparison to the control group; the SQabn subgroup did not differ from the controls. However, the SQabn subgroup showed impaired integrity of the left SCP, whereas the SQnorm subgroup did not. Abnormalities in the right CST in the SQnorm and in the left SCP in SQabn groups suggest that the patients with SQabn represent subgroups with distinct deficits. Moreover, these results demonstrate the involvement of the SCP in the pathogenesis of movement sequencing in schizophrenia.

Links

• CZ.1.05/1.1.00/02.0068, interní kód MU: Name: CEITEC - středoevropský technologický institut (Acronym: CEITEC)

Investor: Ministry of Education, Youth and Sports of the CR, CEITEC - Central European Institute of Technology, 1.1 European Centres of Excellence

• NT13437, research and development project: Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.