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HANÁKOVÁ, Petra, Milan BRÁZDIL, Zdeněk NOVÁK, Jan HEMZA, Jan CHRASTINA, Hana OŠLEJŠKOVÁ, Markéta HERMANOVÁ, Marta PAŽOURKOVÁ, Ivan REKTOR and Robert KUBA. Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy. Seizure. Elsevier, 2014, vol. 23, No 4, p. 266-273. ISSN 1059-1311. doi:10.1016/j.seizure.2013.12.003.
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Basic information
Original name Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy
Authors HANÁKOVÁ, Petra (203 Czech Republic, guarantor, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution), Zdeněk NOVÁK (203 Czech Republic, belonging to the institution), Jan HEMZA (203 Czech Republic), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Hana OŠLEJŠKOVÁ (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Marta PAŽOURKOVÁ (203 Czech Republic), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Robert KUBA (203 Czech Republic, belonging to the institution).
Edition Seizure, Elsevier, 2014, 1059-1311.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.822
RIV identification code RIV/00216224:14110/14:00075760
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.seizure.2013.12.003
UT WoS 000334980700004
Keywords in English Epilepsy surgery; Extratemporal; Long-term outcome; Histopathology; Engel's classification
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 18. 12. 2014 12:25.
Abstract
Purpose: We analyzed the long-term postoperative outcome and possible predictive factors of the outcome in surgically treated patients with refractory extratemporal epilepsy. Methods: We retrospectively analyzed 73 patients who had undergone resective surgery at the Epilepsy Center Brno between 1995 and 2010 and who had reached at least 1 year outcome after the surgery. The average age at surgery was 28.3 +/- 11.4 years. Magnetic resonance imaging (MRI) did not reveal any lesion in 24 patients (32.9%). Surgical outcome was assessed annually using Engel's modified classification until 5 years after surgery and at the latest follow-up visit. Results: Following the surgery, Engel Class I outcome was found in 52.1% of patients after 1 year, in 55.0% after 5 years, and in 50.7% at the last follow-up visit (average 6.15 +/- 3.84 years). Of the patients who reached the 5-year follow-up visit (average of the last follow-up 9.23 years), 37.5% were classified as Engel IA at each follow-up visit. Tumorous etiology and lesions seen in preoperative MRI were associated with significantly better outcome (p = 0.035; p < 0.01). Postoperatively, 9.6% patients had permanent neurological deficits. Conclusion: Surgical treatment of refractory extratemporal epilepsy is an effective procedure. The presence of a visible MRI-detected lesion and tumorous etiology is associated with significantly better outcome than the absence of MRI-detected lesion or other etiology.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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