Mathematical Model of Cardiovascular Disease Risk Based on
Vascular Variability Disorders

J 2014

Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders

SIEGELOVÁ, Jarmila, Jiří DUŠEK, K. OTSUKA and G. CORNELISSEN

Basic information

Original name

Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders

Authors

SIEGELOVÁ, Jarmila (203 Czech Republic, guarantor, belonging to the institution), Jiří DUŠEK (203 Czech Republic), K. OTSUKA (392 Japan) and G. CORNELISSEN (840 United States of America)

Edition

World Heart Journal, Nova Science Publishers Inc, 2014, 1556-4002

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/14:00075804

Organization unit

Faculty of Medicine

Keywords in English

ambulatory blood pressure monitoring (ABPM); essential hypertension; Vascular Variability Disorders (VVDs); heart rate variability (HRV)

Abstract

V originále

Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventionally in the light of the same fixed 24-hour, daytime and nighttime limits for all adults 18 years and older. We show that a chronobiologic approach taking into consideration the circadian characteristics of the BP waveform adjusted for gender and age enable a better estimation of cardiovascular morbidity and mortality risk. Apart from increased 24-hour mean values of BP (MESOR, short for Midline Estimating Statistic of Rhythm), an attribute of MESOR-hypertension (MH), altered patterns of variability in BP and heart rate (HR) are markers of cardiovascular disease risk. Screening for these Vascular Variability Disorders (VVDs) yields a refined diagnosis and prognosis regarding the risk of cardiovascular morbidity and mortality. It also serves as a guide for timed treatment (chronotherapy) when warranted. This chronobiologic approach based on ambulatory BP monitoring remains applicable to manual measurements taken at intervals from the time of awakening to bedtime, preferably with an added measurement around mid-sleep.

Citovat

SIEGELOVÁ, Jarmila, Jiří DUŠEK, K. OTSUKA and G. CORNELISSEN. Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders. World Heart Journal. Nova Science Publishers Inc, 2014, vol. 6, No 1, p. 57-62. ISSN 1556-4002.

@article{1187070,
   author = {Siegelová, Jarmila and Dušek, Jiří and Otsuka, K. and Cornelissen, G.},
   article_number = {1},
   keywords = {ambulatory blood pressure monitoring (ABPM); essential hypertension; Vascular Variability Disorders (VVDs); heart rate variability (HRV)},
   language = {eng},
   issn = {1556-4002},
   journal = {World Heart Journal},
   title = {Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders},
   volume = {6},
   year = {2014}
}

TY  - JOUR
ID  - 1187070
AU  - Siegelová, Jarmila - Dušek, Jiří - Otsuka, K. - Cornelissen, G.
PY  - 2014
TI  - Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders
JF  - World Heart Journal
VL  - 6
IS  - 1
SP  - 57-62
EP  - 57-62
PB  - Nova Science Publishers Inc
SN  - 15564002
KW  - ambulatory blood pressure monitoring (ABPM)
KW  - essential hypertension
KW  - Vascular Variability Disorders (VVDs)
KW  - heart rate variability (HRV)
N2  - Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventionally in the light of the same fixed 24-hour, daytime and nighttime limits for all adults 18 years and older. We show that a chronobiologic approach taking into consideration the circadian characteristics of the BP waveform adjusted for gender and age enable a better estimation of cardiovascular morbidity and mortality risk. Apart from increased 24-hour mean values of BP (MESOR, short for Midline Estimating Statistic of Rhythm), an attribute of MESOR-hypertension (MH), altered patterns of variability in BP and heart rate (HR) are markers of cardiovascular disease risk. Screening for these Vascular Variability Disorders (VVDs) yields a refined diagnosis and prognosis regarding the risk of cardiovascular morbidity and mortality. It also serves as a guide for timed treatment (chronotherapy) when warranted. This chronobiologic approach based on ambulatory BP monitoring remains applicable to manual measurements taken at intervals from the time of awakening to bedtime, preferably with an added measurement around mid-sleep.
ER  -

SIEGELOVÁ, Jarmila, Jiří DUŠEK, K. OTSUKA and G. CORNELISSEN. Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders. \textit{World Heart Journal}. Nova Science Publishers Inc, 2014, vol.~6, No~1, p.~57-62. ISSN~1556-4002.

Detailed Information on Publication Record