Detailed Information on Publication Record
2014
Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders
SIEGELOVÁ, Jarmila, Jiří DUŠEK, K. OTSUKA and G. CORNELISSENBasic information
Original name
Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders
Authors
SIEGELOVÁ, Jarmila (203 Czech Republic, guarantor, belonging to the institution), Jiří DUŠEK (203 Czech Republic), K. OTSUKA (392 Japan) and G. CORNELISSEN (840 United States of America)
Edition
World Heart Journal, Nova Science Publishers Inc, 2014, 1556-4002
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/14:00075804
Organization unit
Faculty of Medicine
Keywords in English
ambulatory blood pressure monitoring (ABPM); essential hypertension; Vascular Variability Disorders (VVDs); heart rate variability (HRV)
Tags
Tags
Reviewed
Změněno: 23/6/2014 15:07, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventionally in the light of the same fixed 24-hour, daytime and nighttime limits for all adults 18 years and older. We show that a chronobiologic approach taking into consideration the circadian characteristics of the BP waveform adjusted for gender and age enable a better estimation of cardiovascular morbidity and mortality risk. Apart from increased 24-hour mean values of BP (MESOR, short for Midline Estimating Statistic of Rhythm), an attribute of MESOR-hypertension (MH), altered patterns of variability in BP and heart rate (HR) are markers of cardiovascular disease risk. Screening for these Vascular Variability Disorders (VVDs) yields a refined diagnosis and prognosis regarding the risk of cardiovascular morbidity and mortality. It also serves as a guide for timed treatment (chronotherapy) when warranted. This chronobiologic approach based on ambulatory BP monitoring remains applicable to manual measurements taken at intervals from the time of awakening to bedtime, preferably with an added measurement around mid-sleep.