SIEGELOVÁ, Jarmila, Jiří DUŠEK, K. OTSUKA and G. CORNELISSEN. Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders. World Heart Journal. Nova Science Publishers Inc, 2014, vol. 6, No 1, p. 57-62. ISSN 1556-4002.
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Basic information
Original name Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders
Authors SIEGELOVÁ, Jarmila (203 Czech Republic, guarantor, belonging to the institution), Jiří DUŠEK (203 Czech Republic), K. OTSUKA (392 Japan) and G. CORNELISSEN (840 United States of America).
Edition World Heart Journal, Nova Science Publishers Inc, 2014, 1556-4002.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/14:00075804
Organization unit Faculty of Medicine
Keywords in English ambulatory blood pressure monitoring (ABPM); essential hypertension; Vascular Variability Disorders (VVDs); heart rate variability (HRV)
Tags EL OK
Tags Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 23/6/2014 15:07.
Abstract
Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventionally in the light of the same fixed 24-hour, daytime and nighttime limits for all adults 18 years and older. We show that a chronobiologic approach taking into consideration the circadian characteristics of the BP waveform adjusted for gender and age enable a better estimation of cardiovascular morbidity and mortality risk. Apart from increased 24-hour mean values of BP (MESOR, short for Midline Estimating Statistic of Rhythm), an attribute of MESOR-hypertension (MH), altered patterns of variability in BP and heart rate (HR) are markers of cardiovascular disease risk. Screening for these Vascular Variability Disorders (VVDs) yields a refined diagnosis and prognosis regarding the risk of cardiovascular morbidity and mortality. It also serves as a guide for timed treatment (chronotherapy) when warranted. This chronobiologic approach based on ambulatory BP monitoring remains applicable to manual measurements taken at intervals from the time of awakening to bedtime, preferably with an added measurement around mid-sleep.
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