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@article{1187242, author = {Raudenská, Martina and Gumulec, Jaromír and Podlaha, Ondrej and Sztalmachová, Markéta and Babula, Petr and Eckschlager, Tomas and Adam, Vojtěch and Kizek, René and Masařík, Michal}, article_location = {Cambridge}, article_number = {1}, doi = {http://dx.doi.org/10.1039/c3mt00132f}, keywords = {METAL-RESPONSIVE ELEMENTS; SINGLE-NUCLEOTIDE POLYMORPHISMS; AMYOTROPHIC-LATERAL-SCLEROSIS; PROSTATE-SPECIFIC ANTIGEN; CENTRAL-NERVOUS-SYSTEM; OXIDATIVE STRESS; GENE-EXPRESSION; IIA GENE; MAMMALIAN METALLOTHIONEIN; TRANSCRIPTION FACTOR}, language = {eng}, issn = {1756-5901}, journal = {Metallomics}, title = {Metallothionein polymorphisms in pathological processes}, volume = {6}, year = {2014} }
TY - JOUR ID - 1187242 AU - Raudenská, Martina - Gumulec, Jaromír - Podlaha, Ondrej - Sztalmachová, Markéta - Babula, Petr - Eckschlager, Tomas - Adam, Vojtěch - Kizek, René - Masařík, Michal PY - 2014 TI - Metallothionein polymorphisms in pathological processes JF - Metallomics VL - 6 IS - 1 SP - 55-68 EP - 55-68 PB - ROYAL SOC CHEMISTRY SN - 17565901 KW - METAL-RESPONSIVE ELEMENTS KW - SINGLE-NUCLEOTIDE POLYMORPHISMS KW - AMYOTROPHIC-LATERAL-SCLEROSIS KW - PROSTATE-SPECIFIC ANTIGEN KW - CENTRAL-NERVOUS-SYSTEM KW - OXIDATIVE STRESS KW - GENE-EXPRESSION KW - IIA GENE KW - MAMMALIAN METALLOTHIONEIN KW - TRANSCRIPTION FACTOR N2 - Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications. This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies. ER -
RAUDENSKÁ, Martina, Jaromír GUMULEC, Ondrej PODLAHA, Markéta SZTALMACHOVÁ, Petr BABULA, Tomas ECKSCHLAGER, Vojtěch ADAM, René KIZEK and Michal MASAŘÍK. Metallothionein polymorphisms in pathological processes. \textit{Metallomics}. Cambridge: ROYAL SOC CHEMISTRY, 2014, vol.~6, No~1, p.~55-68. ISSN~1756-5901. Available from: https://dx.doi.org/10.1039/c3mt00132f.
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