RAUDENSKÁ, Martina, Jaromír GUMULEC, Ondrej PODLAHA, Markéta SZTALMACHOVÁ, Petr BABULA, Tomas ECKSCHLAGER, Vojtěch ADAM, René KIZEK and Michal MASAŘÍK. Metallothionein polymorphisms in pathological processes. Metallomics. Cambridge: ROYAL SOC CHEMISTRY, 2014, vol. 6, No 1, p. 55-68. ISSN 1756-5901. Available from: https://dx.doi.org/10.1039/c3mt00132f.
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Basic information
Original name Metallothionein polymorphisms in pathological processes
Authors RAUDENSKÁ, Martina (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Ondrej PODLAHA (203 Czech Republic), Markéta SZTALMACHOVÁ (203 Czech Republic, belonging to the institution), Petr BABULA (203 Czech Republic), Tomas ECKSCHLAGER (203 Czech Republic), Vojtěch ADAM (203 Czech Republic), René KIZEK (203 Czech Republic) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution).
Edition Metallomics, Cambridge, ROYAL SOC CHEMISTRY, 2014, 1756-5901.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.585
RIV identification code RIV/00216224:14110/14:00075839
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1039/c3mt00132f
UT WoS 000328891100004
Keywords in English METAL-RESPONSIVE ELEMENTS; SINGLE-NUCLEOTIDE POLYMORPHISMS; AMYOTROPHIC-LATERAL-SCLEROSIS; PROSTATE-SPECIFIC ANTIGEN; CENTRAL-NERVOUS-SYSTEM; OXIDATIVE STRESS; GENE-EXPRESSION; IIA GENE; MAMMALIAN METALLOTHIONEIN; TRANSCRIPTION FACTOR
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 24/4/2015 13:09.
Abstract
Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications. This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies.
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