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@article{1187244,
author = {Polanská, Hana and Raudenská, Martina and Gumulec, Jaromír and Sztalmachová, Markéta and Adam, Vojtěch and Kizek, René and Masařík, Michal},
article_location = {Amsterdam},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.oraloncology.2013.12.008},
keywords = {Head and neck cancer; Tumor markers; Cancer; Prognosis; Papillomavirus; miRNA; Saliva},
language = {eng},
issn = {1368-8375},
journal = {Oral oncology},
title = {Clinical significance of head and neck squamous cell cancer biomarkers},
volume = {50},
year = {2014}
}
TY - JOUR
ID - 1187244
AU - Polanská, Hana - Raudenská, Martina - Gumulec, Jaromír - Sztalmachová, Markéta - Adam, Vojtěch - Kizek, René - Masařík, Michal
PY - 2014
TI - Clinical significance of head and neck squamous cell cancer biomarkers
JF - Oral oncology
VL - 50
IS - 3
SP - 168-177
EP - 168-177
PB - Elsevier Science
SN - 13688375
KW - Head and neck cancer
KW - Tumor markers
KW - Cancer
KW - Prognosis
KW - Papillomavirus
KW - miRNA
KW - Saliva
N2 - Head and neck tumors belong among the six leading causes of cancer death worldwide. The predominant type of head and neck tumors consists of squamous cell carcinomas (HNSCC). Early detection of primary tumor and relapse is a key factor for enhancing the survival rate of HNSCC patients, because high rates of cases are recognized at advanced stages. Accordingly, biomarkers suitable for the early detection of HNSCC are sorely needed to improve patient outcomes. HNSCC evolve through a multistep process by the accumulation of genetic and phenotypic changes. Searching for specific biomarkers capable of characterizing each degree is therefore really essential. In this review, genomic and gene expression alterations of HNSCC are summarized and associated with HPV status, clinicopathological conditions, and patient history from the perspective of potential biomarker utilization. The emphasis is placed on non-invasive markers detectable from saliva and blood and clinically relevant studies are mentioned in particular. These include analyses of tumorous tissues, saliva, and blood from patients with histologically defined tumors; cell culture-and other in vitro-based studies with no clinical correlations are rather excluded.
ER -
POLANSKÁ, Hana, Martina RAUDENSKÁ, Jaromír GUMULEC, Markéta SZTALMACHOVÁ, Vojtěch ADAM, René KIZEK a Michal MASAŘÍK. Clinical significance of head and neck squamous cell cancer biomarkers. \textit{Oral oncology}. Amsterdam: Elsevier Science, 2014, roč.~50, č.~3, s.~168-177. ISSN~1368-8375. Dostupné z: https://dx.doi.org/10.1016/j.oraloncology.2013.12.008.
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