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@article{1187261,
author = {Kružliak, Peter and Novák, Jan and Novák, Miroslav},
article_location = {Oxford},
article_number = {1},
doi = {http://dx.doi.org/10.1093/ajh/hpt201},
keywords = {NO donors; VEGF.; angiogenesis inhibitors; blood pressure; hypertension; nitric oxide (NO)},
language = {eng},
issn = {0895-7061},
journal = {American Journal of Hypertension},
title = {Vascular endothelial growth factor inhibitor-induced hypertension: from pathophysiology to prevention and treatment based on long-acting nitric oxide donors.},
volume = {27},
year = {2014}
}
TY - JOUR
ID - 1187261
AU - Kružliak, Peter - Novák, Jan - Novák, Miroslav
PY - 2014
TI - Vascular endothelial growth factor inhibitor-induced hypertension: from pathophysiology to prevention and treatment based on long-acting nitric oxide donors.
JF - American Journal of Hypertension
VL - 27
IS - 1
SP - 3-13
EP - 3-13
PB - Oxford University Press
SN - 08957061
KW - NO donors
KW - VEGF.
KW - angiogenesis inhibitors
KW - blood pressure
KW - hypertension
KW - nitric oxide (NO)
N2 - Hypertension is the most common adverse effect of the inhibitors of vascular endothelial growth factor (VEGF) pathwaybased therapy (VEGF pathway inhibitors therapy, VPI therapy) in cancer patients. VPI includes monoclonal antibodies against VEGF, tyrosine kinase inhibitors, VEGF Traps, and so-called aptamers that may become clinically relevant in the future. All of these substances inhibit the VEGF pathway, which in turn causes a decrease in nitric oxide (NO) and an increase in blood pressure, with the consequent development of hypertension and its final events (e.g., myocardial infarction or stroke). To our knowledge, there is no current study on how to provide an optimal therapy for patients on VPI therapy with hypertension. This review summarizes the roles of VEGF and NO in vessel biology, provides an overview of VPI agents, and suggests a potential treatment procedure for patients with VPI-induced hypertension.
ER -
KRUŽLIAK, Peter, Jan NOVÁK a Miroslav NOVÁK. Vascular endothelial growth factor inhibitor-induced hypertension: from pathophysiology to prevention and treatment based on long-acting nitric oxide donors. \textit{American Journal of Hypertension}. Oxford: Oxford University Press, 2014, roč.~27, č.~1, s.~3-13. ISSN~0895-7061. Dostupné z: https://dx.doi.org/10.1093/ajh/hpt201.
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