J 2014

Symmetry of the Fornix Using Diffusion Tensor Imaging

SBOTO-FRANKENSTEIN, Uta N., Tiffany LAZAR, Bruce R. BOLSTER, Sunny THIND, Patricia Dreessen DE GERVAI et. al.

Basic information

Original name

Symmetry of the Fornix Using Diffusion Tensor Imaging

Authors

SBOTO-FRANKENSTEIN, Uta N. (124 Canada), Tiffany LAZAR (124 Canada), Bruce R. BOLSTER (124 Canada), Sunny THIND (124 Canada), Patricia Dreessen DE GERVAI (124 Canada), Marco L.H. GRUWEL (124 Canada), Stephen D. SMITH (124 Canada) and Boguslaw TOMANEK (616 Poland, guarantor, belonging to the institution)

Edition

Journal of Magnetic Resonance Imaging, Hoboken (USA), Wiley- Blackwell, 2014, 1053-1807

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.210

RIV identification code

RIV/00216224:14740/14:00075878

Organization unit

Central European Institute of Technology

DOI

UT WoS

000342342500022

Keywords in English

Asymmetry; Diffusion tensor imaging; Fornix; TBSS; Tractography

Tags

Tags

International impact, Reviewed
Změněno: 5/12/2014 08:48, Martina Prášilová

Abstract

V originále

Purpose: To: 1) Present fornix tractography in its entirety for 20 healthy individuals to assess variability. 2) Provide individual and groupwise whole tract diffusion parameter symmetry assessments prior to clinical application. 3) Compare whole tract diffusion parameter assessments with tract-based spatial statistics (TBSS). Materials and Methods: Diffusion tensor imaging (DTI) data were acquired on a 3T Siemens magnetic resonance imaging (MRI) system using a single-shot spin echo planar imaging (EPI) sequence. Individual fornix tractography was conducted and whole tract diffusion parameter symmetries assessed. Whole tract results were compared with asymmetry contrasts conducted with voxelwise statistical analysis of diffusion parameters using TBSS. Results: The fornix tract could be visualized in its entirety including the columns, body, crura, and fimbria. Contrary to the crus and body, there were some tractography inconsistencies of the columns and fimbria across subjects. Although whole tract diffusion parameter asymmetries were nonsignificant, fractional anisotropy (FA) values bordered on statistical significance (P = 0.052). Using TBSS, significant FA asymmetries were identified (P less than or equal 0.01, corrected). Conclusion: The findings demonstrate consistency of fornix tractography as well as some variability in the columns and fimbria. While parametric assessment demonstrates diffusion parameter symmetry, permutation-based TBSS analysis reveals significant FA asymmetries in the crura and fimbriae. © 2013 Wiley Periodicals, Inc.