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@article{1188145,
author = {Danhofer, Pavlína and Brázdil, Milan and Ošlejšková, Hana and Kuba, Robert},
article_location = {London},
article_number = {6},
doi = {http://dx.doi.org/10.1016/j.seizure.2014.03.002},
keywords = {Epilepsy; JAE; Juvenile absence epilepsy; Outcome; Seizure control; Therapy},
language = {eng},
issn = {1059-1311},
journal = {Seizure-European journal of epilepsy},
title = {Long-term seizure outcome in patients with juvenile absence epilepsy; a retrospective study in a tertiary referral center},
volume = {23},
year = {2014}
}
TY - JOUR
ID - 1188145
AU - Danhofer, Pavlína - Brázdil, Milan - Ošlejšková, Hana - Kuba, Robert
PY - 2014
TI - Long-term seizure outcome in patients with juvenile absence epilepsy; a retrospective study in a tertiary referral center
JF - Seizure-European journal of epilepsy
VL - 23
IS - 6
SP - 443-447
EP - 443-447
PB - W.B. Saunders Ltd.
SN - 10591311
KW - Epilepsy
KW - JAE
KW - Juvenile absence epilepsy
KW - Outcome
KW - Seizure control
KW - Therapy
N2 - Purpose The study aim was to evaluate pharmacotherapy effects and long-term seizure outcomes in patients with juvenile absence epilepsy (JAE) during a five-year follow-up period. The secondary aim was to identify factors from patient history and determine their influence on seizure control. Method We retrospectively studied 46 patients with JAE in the period between 2006 and 2011. The age at seizure onset, onset seizure type, family history of epilepsy, status epilepticus in history, medication history, and the rate of seizure control were studied. Results There were 30 females (65.2%) and 16 males (34.8%) in the study. The mean age at seizure onset was 12.9 ± 5.6 years (ranged from 3 to 28 years). In 30 patients (65.2%), seizure onset was with absences, in 15 patients (32.6%) with generalized tonic-clonic seizure (GTCS), and in 1 patient (2.2%) with absence status. In 43 patients (93.5%), GTCS occurred in the course of the disease. Family history for epilepsy was positive in 10 patients (21.7%). In the five-year follow-up period, seizure freedom (Group 1) was achieved in 7 patients (15.2%). In total, 22 patients (47.8%) were classified into the groups involving very poor seizure control and antiepileptic drug resistance (Groups 5 and 6). The mean number of antiepileptic drugs (AEDs) used in the course of the disease in appropriate therapeutic doses was 3.8 ± 2.3 (1-10 AEDs). Conclusion The study results show that almost half of JAE patients have poor seizure control with a high rate of pharmacoresistance. The outcome of JAE can be very uncertain.
ER -
DANHOFER, Pavlína, Milan BRÁZDIL, Hana OŠLEJŠKOVÁ and Robert KUBA. Long-term seizure outcome in patients with juvenile absence epilepsy; a retrospective study in a tertiary referral center. \textit{Seizure-European journal of epilepsy}. London: W.B. Saunders Ltd., 2014, vol.~23, No~6, p.~443-447. ISSN~1059-1311. Available from: https://dx.doi.org/10.1016/j.seizure.2014.03.002.
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