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@article{1192707,
author = {Denev, Petko and Kratchanova, Maria and Číž, Milan and Lojek, Antonín and Vašíček, Ondřej and Blazheva, Denitsa and Nedelcheva, Plamena and Vojtek, Libor and Hyršl, Pavel},
article_location = {Warsaw},
article_number = {2},
keywords = {herbs; polyphenols; antioxidant activity; antimicrobial activity; phagocytes; reactive oxygen species},
language = {eng},
issn = {0001-527X},
journal = {Acta Biochimica Polonica},
title = {Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts},
url = {http://www.actabp.pl/pdf/2_2014/359.pdf},
volume = {61},
year = {2014}
}
TY - JOUR
ID - 1192707
AU - Denev, Petko - Kratchanova, Maria - Číž, Milan - Lojek, Antonín - Vašíček, Ondřej - Blazheva, Denitsa - Nedelcheva, Plamena - Vojtek, Libor - Hyršl, Pavel
PY - 2014
TI - Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts
JF - Acta Biochimica Polonica
VL - 61
IS - 2
SP - 359-367
EP - 359-367
PB - Acta Biochimica Polonica
SN - 0001527X
KW - herbs
KW - polyphenols
KW - antioxidant activity
KW - antimicrobial activity
KW - phagocytes
KW - reactive oxygen species
UR - http://www.actabp.pl/pdf/2_2014/359.pdf
L2 - http://www.actabp.pl/pdf/2_2014/359.pdf
N2 - The present study provides a comprehensive data on the antioxidant, antimicrobial and neutrophil-modulating activities of extracts from six medicinal plants — blackberry (Rubus fruticosus) leaves, chokeberry (Aronia melanocarpa) leaves, hawthorn (Crataegus monogyna) leaves, lady’s mantle (Alchemilla glabra) aerial parts, meadowsweet (Filipendula ulmaria) aerial parts and raspberry (Rubus idaeus) leaves. In order to analyze the antioxidant activity of the herbs, several methods (ORAC, TRAP, HORAC and inhibition of lipid peroxidation) were used. Blackberry leaves and meadowsweet extracts revealed the highest antioxidant activities via all methods. All extracts studied blocked almost completely the opsonized zymosan particle-activated ROS production by neutrophils from human whole blood. On the other hand, the effect of extracts on phorbol myristate acetate-activated ROS production was much milder and even nonsignificant in the case of chokeberry leaves. This latter result suggests that extracts (apart from their antioxidative activity) interfere with the signaling cascade of phagocyte activation upstream of the protein kinase C activation. The antimicrobial activity of the investigated extracts against 11 human pathogens was investigated using three different methods. Meadowsweet and blackberry leaves extracts had the highest antimicrobial effect and the lowest minimal inhibiting concentrations (MICs) against the microorganisms tested.
ER -
DENEV, Petko, Maria KRATCHANOVA, Milan ČÍŽ, Antonín LOJEK, Ondřej VAŠÍČEK, Denitsa BLAZHEVA, Plamena NEDELCHEVA, Libor VOJTEK and Pavel HYRŠL. Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts. \textit{Acta Biochimica Polonica}. Warsaw: Acta Biochimica Polonica, 2014, vol.~61, No~2, p.~359-367. ISSN~0001-527X.
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