Evidence for altered thiamine metabolism in diabetes: Is there
a potential to oppose gluco- and lipotoxicity by rational
supplementation?

J 2014

Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?

PÁCAL, Lukáš; Katarína KURICOVÁ a Kateřina KAŇKOVÁ

Základní údaje

Originální název

Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?

Autoři

PÁCAL, Lukáš (203 Česká republika, garant, domácí); Katarína KURICOVÁ (703 Slovensko, domácí) a Kateřina KAŇKOVÁ (203 Česká republika, domácí)

Vydání

World Journal of Diabetes, Pleasanton, Baishideng Publishing Group Inc. 2014, 1948-9358

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/14:00080141

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Diabetes; Thiamine; Vitamin B1; Transketolase; Benfotiamine; Hyperglycemia; Nephropathy; Metabolic syndrome; Cardiovascular disease; Chronic kidney disease

Štítky

EL OK

Změněno: 7. 8. 2014 14:26, Soňa Böhmová

Anotace

V originále

Growing prevalence of diabetes (type 2 as well as type 1) and its related morbidity due to vascular complications creates a large burden on medical care worldwide. Understanding the molecular pathogenesis of chronic micro-, macro- and avascular complications mediated by hyperglycemia is of crucial importance since novel therapeutic targets can be identified and tested. Thiamine (vitamin B1) is an essential cofactor of several enzymes involved in carbohydrate metabolism and published data suggest that thiamine metabolism in diabetes is deficient. This review aims to point out the physiological role of thiamine in metabolism of glucose and amino acids, to present overview of thiamine metabolism and to describe the consequences of thiamine deficiency (either clinically manifest or latent). Furthermore, we want to explain why thiamine demands are increased in diabetes and to summarise data indicating thiamine mishandling in diabetics (by review of the studies mapping the prevalence and the degree of thiamine deficiency in diabetics). Finally, we would like to summarise the evidence for the beneficial effect of thiamine supplementation in progression of hyperglycemia- related pathology and, therefore, to justify its importance in determining the harmful impact of hyperglycemia in diabetes. Based on the data presented it could be concluded that although experimental studies mostly resulted in beneficial effects, clinical studies of appropriate size and duration focusing on the effect of thiamine supplementation/therapy on hard endpoints are missing at present. Moreover, it is not currently clear which mechanisms contribute to the deficient action of thiamine in diabetes most. Experimental studies on the molecular mechanisms of thiamine deficiency in diabetes are critically needed before clear answer to diabetes community could be given.

Návaznosti

NT13198, projekt VaV

Název: Pentózový cyklus jako potenciální nový terapeutický cíl v prevenci diabetických komplikací

Investor: Ministerstvo zdravotnictví ČR, Pentózový cyklus jako potenciální nový terapeutický cíl v prevenci diabetických komplikací

Citovat

PÁCAL, Lukáš; Katarína KURICOVÁ a Kateřina KAŇKOVÁ. Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? World Journal of Diabetes. Pleasanton: Baishideng Publishing Group Inc., 2014, roč. 5, č. 3, s. 288-295. ISSN 1948-9358.

@article{1194374,
   author = {Pácal, Lukáš and Kuricová, Katarína and Kaňková, Kateřina},
   article_location = {Pleasanton},
   article_number = {3},
   keywords = {Diabetes; Thiamine; Vitamin B1; Transketolase; Benfotiamine; Hyperglycemia; Nephropathy; Metabolic syndrome; Cardiovascular disease; Chronic kidney disease},
   language = {eng},
   issn = {1948-9358},
   journal = {World Journal of Diabetes},
   title = {Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?},
   volume = {5},
   year = {2014}
}

TY  - JOUR
ID  - 1194374
AU  - Pácal, Lukáš - Kuricová, Katarína - Kaňková, Kateřina
PY  - 2014
TI  - Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?
JF  - World Journal of Diabetes
VL  - 5
IS  - 3
SP  - 288-295
EP  - 288-295
PB  - Baishideng Publishing Group Inc.
SN  - 19489358
KW  - Diabetes
KW  - Thiamine
KW  - Vitamin B1
KW  - Transketolase
KW  - Benfotiamine
KW  - Hyperglycemia
KW  - Nephropathy
KW  - Metabolic syndrome
KW  - Cardiovascular disease
KW  - Chronic kidney disease
N2  - Growing prevalence of diabetes (type 2 as well as type 1) and its related morbidity due to vascular complications creates a large burden on medical care worldwide. Understanding the molecular pathogenesis of chronic micro-, macro- and avascular complications mediated by hyperglycemia is of crucial importance since novel therapeutic targets can be identified and tested. Thiamine (vitamin B1) is an essential cofactor of several enzymes involved in carbohydrate metabolism and published data suggest that thiamine metabolism in diabetes is deficient. This review aims to point out the physiological role of thiamine in metabolism of glucose and amino acids, to present overview of thiamine metabolism and to describe the consequences of thiamine deficiency (either clinically manifest or latent). Furthermore, we want to explain why thiamine demands are increased in diabetes and to summarise data indicating thiamine mishandling in diabetics (by review of the studies mapping the prevalence and the degree of thiamine deficiency in diabetics). Finally, we would like to summarise the evidence for the beneficial effect of thiamine supplementation in progression of hyperglycemia- related pathology and, therefore, to justify its importance in determining the harmful impact of hyperglycemia in diabetes. Based on the data presented it could be concluded that although experimental studies mostly resulted in beneficial effects, clinical studies of appropriate size and duration focusing on the effect of thiamine supplementation/therapy on hard endpoints are missing at present. Moreover, it is not currently clear which mechanisms contribute to the deficient action of thiamine in diabetes most. Experimental studies on the molecular mechanisms of thiamine deficiency in diabetes are critically needed before clear answer to diabetes community could be given.
ER  -

PÁCAL, Lukáš; Katarína KURICOVÁ a Kateřina KAŇKOVÁ. Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? \textit{World Journal of Diabetes}. Pleasanton: Baishideng Publishing Group Inc., 2014, roč.~5, č.~3, s.~288-295. ISSN~1948-9358.

Přehled o publikaci