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@article{1194797,
author = {Meluzín, Jaroslav and Hude, Petr and Leinveber, Pavel and Krejčí, Jan and Špinarová, Lenka and Bedáňová, Helena and Podroužková, Helena and Štěpánová, Radka and Nemec, Petr},
article_location = {Olomouc},
article_number = {2},
doi = {http://dx.doi.org/10.5507/bp.2013.095},
keywords = {heart transplantation; heart failure; pulmonary capillary wedge pressure; diastolic dysfunction},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers, Olomouc: Palacky University},
title = {High prevalence of exercise-induced heart failure with normal ejection fraction in post-heart transplant patients},
volume = {158},
year = {2014}
}
TY - JOUR
ID - 1194797
AU - Meluzín, Jaroslav - Hude, Petr - Leinveber, Pavel - Krejčí, Jan - Špinarová, Lenka - Bedáňová, Helena - Podroužková, Helena - Štěpánová, Radka - Nemec, Petr
PY - 2014
TI - High prevalence of exercise-induced heart failure with normal ejection fraction in post-heart transplant patients
JF - Biomedical Papers, Olomouc: Palacky University
VL - 158
IS - 2
SP - 295-302
EP - 295-302
PB - Palacky University
SN - 12138118
KW - heart transplantation
KW - heart failure
KW - pulmonary capillary wedge pressure
KW - diastolic dysfunction
N2 - Aim. Post-heart transplant patients are at increased risk of diastolic dysfunction. The aim of this study was to assess the prevalence of isolated only exercise-induced heart failure with normal ejection fraction (HFNEF) in heart transplant recipients. Methods and Results. To determine pulmonary capillary wedge pressure (PCWP) at rest and during exercise, 81 patients after orthotopic heart transplantation with normal left ventricular ejection fraction (LVEF) underwent exercise right heart catheterization with simultaneous exercise echocardiography. Based on PCWP values, the patients were divided into three groups. Twenty-one patients had no evidence of HFNEF (PCWP at rest < 15 mmHg, maximal PCWP during exercise < 25 mmHg, prevalence 26%). Forty-seven subjects were found to have only exercise-induced HFNEF (PCWP at rest < 15 mmHg, maximal PCWP during exercise >= 25 mmHg, prevalence 58%). Thirteen patients had HFNEF already at rest (PCWP >= 15 mmHg at rest, prevalence 16%). Of the noninvasive parameters obtained at rest, multivariate regression analysis identified LV mass index adjusted for allograft age to be an independent predictor of exercise-induced HFNEF. Conclusions. In heart transplant recipients with normal LVEF, there is a high prevalence of exercise-induced HFNEF. LV mass index adjusted for allograft age is predictive of exercise-induced HFNEF.
ER -
MELUZÍN, Jaroslav, Petr HUDE, Pavel LEINVEBER, Jan KREJČÍ, Lenka ŠPINAROVÁ, Helena BEDÁŇOVÁ, Helena PODROUŽKOVÁ, Radka ŠTĚPÁNOVÁ a Petr NEMEC. High prevalence of exercise-induced heart failure with normal ejection fraction in post-heart transplant patients. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, roč.~158, č.~2, s.~295-302. ISSN~1213-8118. doi:10.5507/bp.2013.095. 2014.
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