Functional divergence and population replacement in British bank voles

KOTLÍK, Petr, Silvia MARKOVÁ, Libor VOJTEK, Mateusz KONCZAL, Pavel HYRŠL and Jeremy SAERLE. Functional divergence and population replacement in British bank voles. In 14th Rodens et Spatium. 2014.

Basic information

Original name

Functional divergence and population replacement in British bank voles

Name in Czech

Functional divergence and population replacement in British bank voles

Authors

KOTLÍK, Petr (203 Czech Republic, guarantor), Silvia MARKOVÁ (203 Czech Republic), Libor VOJTEK (203 Czech Republic, belonging to the institution), Mateusz KONCZAL (616 Poland), Pavel HYRŠL (203 Czech Republic) and Jeremy SAERLE (826 United Kingdom of Great Britain and Northern Ireland)

Edition

14th Rodens et Spatium, 2014

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Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/14:00076162

Organization unit

Faculty of Science

Keywords (in Czech)

bank vole; haemoglobin; Clethrionomys glareolus; oxidative stress; colonization

Keywords in English

bank vole; haemoglobin; Clethrionomys glareolus; oxidative stress; colonization

Tags

International impact, Reviewed

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Abstract

V originále

We describe the functional consequences of haemoglobin divergence between two British populations of the bank vole (Clethrionomys$glareolus), one that partially replaced the other during endVglacial colonization from mainland, to examine the possibility of adaptive processes in explaining the replacement. We determine the amino acid substitution of serine for cysteine in the beta haemoglobin chain as the mutation underlying the divergence between the two populations. We demonstrate that this mutation increases the tolerance of bank vole blood cells to oxidative stress. Because levels of oxidative stress correlate with a variety of physiological and pathological states, we argue that the mutation may have conveyed a competitive advantage over the first colonists, promoting the replacement. Our study thus provides striking evidence for physiological differences between populations that spread at the expense of one another during colonization of an area from different glacial refugia, and suggests that selection may have had an important role in endVglacial colonization history and, thus, in establishing the current distributions of species.

In Czech

We describe the functional consequences of haemoglobin divergence between two British populations of the bank vole (Clethrionomys$glareolus), one that partially replaced the other during endVglacial colonization from mainland, to examine the possibility of adaptive processes in explaining the replacement. We determine the amino acid substitution of serine for cysteine in the beta haemoglobin chain as the mutation underlying the divergence between the two populations. We demonstrate that this mutation increases the tolerance of bank vole blood cells to oxidative stress. Because levels of oxidative stress correlate with a variety of physiological and pathological states, we argue that the mutation may have conveyed a competitive advantage over the first colonists, promoting the replacement. Our study thus provides striking evidence for physiological differences between populations that spread at the expense of one another during colonization of an area from different glacial refugia, and suggests that selection may have had an important role in endVglacial colonization history and, thus, in establishing the current distributions of species.