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@proceedings{1195644,
author = {Bébarová, Markéta and Matejovič, Peter and Hošek, Jan and Šimurdová, Milena and Šimurda, Jiří},
booktitle = {Physiology 2014},
keywords = {inward rectifier, ethanol, rat atrial myocytes, human Kir2.3},
language = {eng},
title = {Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels},
year = {2014}
}
TY - CONF
ID - 1195644
AU - Bébarová, Markéta - Matejovič, Peter - Hošek, Jan - Šimurdová, Milena - Šimurda, Jiří
PY - 2014
TI - Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels
KW - inward rectifier, ethanol, rat atrial myocytes, human Kir2.3
N2 - This is the first study demonstrating an effect of ethanol on the atrial IK1. The ethanol effect was apparent in a clinically relevant concentration and partly differed in rat atrial myocytes and in the expressed human Kir2.3 channels. The decline of IK1-inhibition during application of ethanol observed in rat atrial cells along with the following increase of IK1 in a part of these cells may be caused by an unknown mechanism which is not present in the human Kir2.3 channels expressed in CHO cells. Our experimental data suggest that ethanol-induced changes of the atrial IK1 might participate in the reported alterations of atrial electrophysiology under alcohol consumption.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Jan HOŠEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels. In \textit{Physiology 2014}. 2014.
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