Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Jan HOŠEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels. In Physiology 2014. 2014.

Basic information

• Original name: Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels
• Authors: BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Jan HOŠEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA.
• Edition: Physiology 2014, 2014.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30105 Physiology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• Keywords in English: inward rectifier, ethanol, rat atrial myocytes, human Kir2.3
• Tags: International impact, Reviewed

Abstract

This is the first study demonstrating an effect of ethanol on the atrial IK1. The ethanol effect was apparent in a clinically relevant concentration and partly differed in rat atrial myocytes and in the expressed human Kir2.3 channels. The decline of IK1-inhibition during application of ethanol observed in rat atrial cells along with the following increase of IK1 in a part of these cells may be caused by an unknown mechanism which is not present in the human Kir2.3 channels expressed in CHO cells. Our experimental data suggest that ethanol-induced changes of the atrial IK1 might participate in the reported alterations of atrial electrophysiology under alcohol consumption.

Links

• NT14301, research and development project: Name: Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?

Investor: Ministry of Health of the CR