Detailed Information on Publication Record
2014
Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Jan HOŠEK, Milena ŠIMURDOVÁ, Jiří ŠIMURDA et. al.Basic information
Original name
Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels
Authors
Edition
Physiology 2014, 2014
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30105 Physiology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Organization unit
Faculty of Medicine
Keywords in English
inward rectifier, ethanol, rat atrial myocytes, human Kir2.3
Tags
International impact, Reviewed
Změněno: 25/8/2014 16:54, doc. MUDr. Markéta Bébarová, Ph.D.
Abstract
V originále
This is the first study demonstrating an effect of ethanol on the atrial IK1. The ethanol effect was apparent in a clinically relevant concentration and partly differed in rat atrial myocytes and in the expressed human Kir2.3 channels. The decline of IK1-inhibition during application of ethanol observed in rat atrial cells along with the following increase of IK1 in a part of these cells may be caused by an unknown mechanism which is not present in the human Kir2.3 channels expressed in CHO cells. Our experimental data suggest that ethanol-induced changes of the atrial IK1 might participate in the reported alterations of atrial electrophysiology under alcohol consumption.
Links
| NT14301, research and development project |
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