VARGA, Marian, Monika ZOUHAROVÁ, Roman PANTŮČEK, Marek MOŠA and Jiří DOŠKAŘ. Analyzing the defense strategies of Staphylococcus aureus strains against polyvalent bacteriophages. In International Symposium on Staphylococci & Staphylococcal Infections - ISSSI 2014, Chicago, IL, USA. 2014.
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Basic information
Original name Analyzing the defense strategies of Staphylococcus aureus strains against polyvalent bacteriophages
Authors VARGA, Marian, Monika ZOUHAROVÁ, Roman PANTŮČEK, Marek MOŠA and Jiří DOŠKAŘ.
Edition International Symposium on Staphylococci & Staphylococcal Infections - ISSSI 2014, Chicago, IL, USA, 2014.
Other information
Original language English
Type of outcome Conference abstract
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization unit Faculty of Science
Tags International impact
Changed by Changed by: Mgr. et Mgr. Veronika Oškerová, Ph.D., učo 134438. Changed: 18/3/2016 13:00.
Abstract
The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and inovative antimicrobial strategies. One of them is phage therapy that represents a promising alternative to the use of antibiotics for combating bacterial infections. Some strains, however, are resistant to therapeutic bacteriophages, which may decrease the effectivity of phage-based drugs. In our study, we analyzed causes responsible for this resistance, mainly: (i) efficacy of phage adsorption to bacterial cells; (ii) interference with the products of the prophage-borne genes in lysogenic strains; and (iii) effect of CRISPR-Cas elements.
Links
EE2.3.20.0183, research and development projectName: Centrum experimentální biomedicíny
EE2.4.31.0155, research and development projectName: Partnerství a sítě pro spolupráci v experimentální biologii
TA01010405, research and development projectName: Výzkum stafylokokových bakteriofágových mutant s širokým spektrem hostitelů (Acronym: TAČR/IMUNA-1)
Investor: Technology Agency of the Czech Republic
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