CHMELÍKOVÁ, Monika, Lukáš PÁCAL, Lenka ŠPINAROVÁ and Anna VAŠKŮ. Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels. Biomedical Papers. Olomouc: Palacky University, 2015, vol. 159, No 4, p. 535-539. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2014.043.
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Basic information
Original name Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels
Name in Czech Asociace polymorfizmů v genech endokanabinoidního systému s infarktem myokardu a plazmatickou hladinou cholesterolu
Authors CHMELÍKOVÁ, Monika (203 Czech Republic, guarantor, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution), Lenka ŠPINAROVÁ (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition Biomedical Papers, Olomouc, Palacky University, 2015, 1213-8118.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.924
RIV identification code RIV/00216224:14110/15:00082099
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.5507/bp.2014.043
UT WoS 000366566700004
Keywords (in Czech) chronické srdeční selhání; endokanabinoidní systém; hydroláza amidů mastných kyselin
Keywords in English chronic heart failure; endocannabinoid system; fatty acid amide hydrolase; cannabinoid receptor; myocardial infarction cholesterol
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 8/4/2016 09:44.
Abstract
Aims. The aim of this study was to investigate the relationship between selected symptoms of chronic heart failure (myocardial infarction, plasma cholesterol level) and single nucleotide polymorphisms (SNPs) in the FAAH and CNR1 genes. Methods. A case – control study involving 155 patients with chronic heart failure and 169 age- and sex-matched healthy subjects. We detected SNPs 385 C/A (rs324420) in the FAAH and 1359 G/A (rs1049353) in the CNR1 genes using the polymerase chain reaction and restriction analysis. Genotype and allele frequencies were compared between patients and controls as well as between patients with and without myocardial infarction. Results. No significant differences in genotype or allelic frequencies between patients and controls were found (P > 0.05). Carriers of the FAAH A allele had a 2.37-fold increase in the risk of myocardial infarction (odds ratio 2.37, 95% confidence interval 1.36-6.93, P = 0.01). Homozygous carriers of genotype AA of CNR1 SNP 1359 had significantly higher plasma cholesterol levels than carriers of GG and GA genotypes in patients (P = 0.04). Conclusions. The study results suggest a role for allele A of the FAAH 385 variant as a risk factor for myocardial infarction. Genotype AA of CNR1 1359 variant probably affects plasma cholesterol levels. Pharmacological intervention in this system could modify the therapeutic approach to certain cardiovascular disorders.
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