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@article{1197185,
author = {Lipková, Jolana and Šplíchal, Zbyněk and Bienertová Vašků, Julie and Jurajda, Michal and Pařenica, Jiří and Vašků, Anna and Pávková Goldbergová, Monika},
article_location = {London},
article_number = {8},
doi = {http://dx.doi.org/10.3109/07420528.2014.921790},
keywords = {Circadian clock; Per3 VNTR polymorphism; cosinor analysis; heart failure; myocardial infarction},
language = {eng},
issn = {0742-0528},
journal = {Chronobiology International},
title = {Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation},
volume = {31},
year = {2014}
}
TY - JOUR
ID - 1197185
AU - Lipková, Jolana - Šplíchal, Zbyněk - Bienertová Vašků, Julie - Jurajda, Michal - Pařenica, Jiří - Vašků, Anna - Pávková Goldbergová, Monika
PY - 2014
TI - Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation
JF - Chronobiology International
VL - 31
IS - 8
SP - 878-890
EP - 878-890
PB - Informa Healthcare
SN - 07420528
KW - Circadian clock
KW - Per3 VNTR polymorphism
KW - cosinor analysis
KW - heart failure
KW - myocardial infarction
N2 - It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemical processes. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac metabolism and function and increase the susceptibility of cardiovascular diseases. One of the key components of the human clock system PERIOD3 (PER3) has been recently demonstrated to affect circadian expression of various genes in different tissues, including the heart. The variable number tandem repeat (VNTR) polymorphism (rs57875989) in gene Period3 (Per3) is related to multiple phenotypic parameters, including diurnal preference, sleep homeostasis, infection and cancer. The aim of our study was to investigate the effect of this polymorphism in AMI with ST elevation (STEMI). The study subjects (314 patients of Caucasian origin with STEMI, and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific polymerase chain reaction. A gender difference in circadian rhythmicity of pain onset was observed with significant circadian pattern in men. Furthermore, the Per3(5/5) variant carriers were associated with higher levels of interleukin-6, B-type natriuretic peptide and lower vitamin A levels. By using cosinor analysis we observed different circadian distribution patterns of AMI onset at the level of genotype and allelic frequencies. Genotypes with at least one 4-repeat allele (Per3(4/5) and Per3(4/4)) (N = 264) showed remarkable circadian activity in comparison with Per3(5/5) (N = 50), especially in men. No significant differences in genotype and/or allele frequencies of Per3 VNTR polymorphism were observed when comparing STEMI cases and controls. Our results indicate that the Per3 VNTR may contribute to modulation of cardiac functions and interindividual differences in development and progression of myocardial infarction.
ER -
LIPKOVÁ, Jolana, Zbyněk ŠPLÍCHAL, Julie BIENERTOVÁ VAŠKŮ, Michal JURAJDA, Jiří PAŘENICA, Anna VAŠKŮ and Monika PÁVKOVÁ GOLDBERGOVÁ. Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation. \textit{Chronobiology International}. London: Informa Healthcare, 2014, vol.~31, No~8, p.~878-890. ISSN~0742-0528. Available from: https://dx.doi.org/10.3109/07420528.2014.921790.
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