Functional Imaging of the Cerebellum and Basal Ganglia During
Predictive Motor Timing in Early Parkinson's Disease

J 2014

Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease

ČECHOVÁ, Ivica, Ovidiu V LUNGU, Radek MAREČEK, Michal MIKL, Tomáš GESCHEIDT et. al.

Basic information

Original name

Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease

Authors

ČECHOVÁ, Ivica (703 Slovakia, belonging to the institution), Ovidiu V LUNGU (124 Canada), Radek MAREČEK (203 Czech Republic, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Tomáš GESCHEIDT (203 Czech Republic), Petr KRUPA (203 Czech Republic) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neuroimaging, Hoboken, USA, WILEY-BLACKWELL, 2014, 1051-2284

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.734

RIV identification code

RIV/00216224:14110/14:00076462

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/j.1552-6569.2011.00663.x

UT WoS

000329509100008

Keywords in English

Basal ganglia; cerebellum; fMRI; Parkinson's disease; prediction; timing

Abstract

V originále

BACKGROUND AND PURPOSEThe basal ganglia and the cerebellum have both emerged as important structures involved in the processing of temporal information. METHODSWe examined the roles of the cerebellum and striatum in predictive motor timing during a target interception task in healthy individuals (HC group; n = 21) and in patients with early Parkinson's disease (early stage PD group; n = 20) using functional magnetic resonance imaging. RESULTSDespite having similar hit ratios, the PD failed more often than the HC to postpone their actions until the right moment and to adapt their behavior from one trial to the next. We found more activation in the right cerebellar lobule VI in HC than in early stage PD during successful trials. Successful trial-by-trial adjustments were associated with higher activity in the right putamen and lobule VI of the cerebellum in HC. CONCLUSIONSWe conclude that both the cerebellum and striatum are involved in predictive motor timing tasks. The cerebellar activity is associated exclusively with the postponement of action until the right moment, whereas both the cerebellum and striatum are needed for successful adaptation of motor actions from one trial to the next. We found a general hypoactivation'' of basal ganglia and cerebellum in early stage PD relative to HC, indicating that even in early stages of the PD there could be functional perturbations in the motor system beyond striatum.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Files attached

EL_Functional_imaging.pdf

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Citovat

ČECHOVÁ, Ivica, Ovidiu V LUNGU, Radek MAREČEK, Michal MIKL, Tomáš GESCHEIDT, Petr KRUPA and Martin BAREŠ. Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease. Journal of Neuroimaging. Hoboken, USA: WILEY-BLACKWELL, 2014, vol. 24, No 1, p. 45-53. ISSN 1051-2284. Available from: https://dx.doi.org/10.1111/j.1552-6569.2011.00663.x.

@article{1197981,
   author = {Čechová, Ivica and Lungu, Ovidiu V and Mareček, Radek and Mikl, Michal and Gescheidt, Tomáš and Krupa, Petr and Bareš, Martin},
   article_location = {Hoboken, USA},
   article_number = {1},
   doi = {http://dx.doi.org/10.1111/j.1552-6569.2011.00663.x},
   keywords = {Basal ganglia; cerebellum; fMRI; Parkinson's disease; prediction; timing},
   language = {eng},
   issn = {1051-2284},
   journal = {Journal of Neuroimaging},
   title = {Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease},
   volume = {24},
   year = {2014}
}

TY  - JOUR
ID  - 1197981
AU  - Čechová, Ivica - Lungu, Ovidiu V - Mareček, Radek - Mikl, Michal - Gescheidt, Tomáš - Krupa, Petr - Bareš, Martin
PY  - 2014
TI  - Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease
JF  - Journal of Neuroimaging
VL  - 24
IS  - 1
SP  - 45-53
EP  - 45-53
PB  - WILEY-BLACKWELL
SN  - 10512284
KW  - Basal ganglia
KW  - cerebellum
KW  - fMRI
KW  - Parkinson's disease
KW  - prediction
KW  - timing
N2  - BACKGROUND AND PURPOSEThe basal ganglia and the cerebellum have both emerged as important structures involved in the processing of temporal information. METHODSWe examined the roles of the cerebellum and striatum in predictive motor timing during a target interception task in healthy individuals (HC group; n = 21) and in patients with early Parkinson's disease (early stage PD group; n = 20) using functional magnetic resonance imaging. RESULTSDespite having similar hit ratios, the PD failed more often than the HC to postpone their actions until the right moment and to adapt their behavior from one trial to the next. We found more activation in the right cerebellar lobule VI in HC than in early stage PD during successful trials. Successful trial-by-trial adjustments were associated with higher activity in the right putamen and lobule VI of the cerebellum in HC. CONCLUSIONSWe conclude that both the cerebellum and striatum are involved in predictive motor timing tasks. The cerebellar activity is associated exclusively with the postponement of action until the right moment, whereas both the cerebellum and striatum are needed for successful adaptation of motor actions from one trial to the next. We found a general hypoactivation'' of basal ganglia and cerebellum in early stage PD relative to HC, indicating that even in early stages of the PD there could be functional perturbations in the motor system beyond striatum.
ER  -

ČECHOVÁ, Ivica, Ovidiu V LUNGU, Radek MAREČEK, Michal MIKL, Tomáš GESCHEIDT, Petr KRUPA and Martin BAREŠ. Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease. \textit{Journal of Neuroimaging}. Hoboken, USA: WILEY-BLACKWELL, 2014, vol.~24, No~1, p.~45-53. ISSN~1051-2284. Available from: https://dx.doi.org/10.1111/j.1552-6569.2011.00663.x.

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