| CORNELY, O.A., S. ARIKAN- AKDAGLI, E. DANNAOUI, A.H. GROLL, K. LAGROU, A. CHAKRABARTI, F. LANTERNIER, L. PAGANO, A. SKIADA, M. AKOVA, M.C. ARENDRUP, T. BOEKHOUT, A. CHOWDHARY, M. CUENCA- ESTRELLA, Tomáš FREIBERGER, J. GUINEA, J. GUARRO, S. DE HOOG, W. HOPE, E. JOHNSON, S. KATHURIA, M. LACKNER, C. LASS- FLÖRL, O. LORTHOLARY, J.F. MEIS, J. MELATIADIS, P. MUNOZ, M. RICHARDSON, E. ROILIDES, A.M. TORTORANO, A.J. ULLMANN, A. VAN DIEPENINGEN, P. VERWEIJ a G. PETRIKKOS. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013. Clinical Microbiology and Infection. Hoboken (USA): Wiley- Blackwell, 2014, roč. 20, April, s. 5-26. ISSN 1198-743X. doi:10.1111/1469-0691.12371. |
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@article{1198044,
author = {Cornely, O.A. and Arikanand Akdagli, S. and Dannaoui, E. and Groll, A.H. and Lagrou, K. and Chakrabarti, A. and Lanternier, F. and Pagano, L. and Skiada, A. and Akova, M. and Arendrup, M.C. and Boekhout, T. and Chowdhary, A. and Cuencaand Estrella, M. and Freiberger, Tomáš and Guinea, J. and Guarro, J. and de Hoog, S. and Hope, W. and Johnson, E. and Kathuria, S. and Lackner, M. and Lassand Flörl, C. and Lortholary, O. and Meis, J.F. and Melatiadis, J. and Munoz, P. and Richardson, M. and Roilides, E. and Tortorano, A.M. and Ullmann, A.J. and van Diepeningen, A. and Verweij, P. and Petrikkos, G.},
article_location = {Hoboken (USA)},
article_number = {April},
doi = {http://dx.doi.org/10.1111/1469-0691.12371},
keywords = {LIPOSOMAL AMPHOTERICIN-B; INVASIVE FUNGAL-INFECTIONS; ORBITAL-CEREBRAL MUCORMYCOSIS; IN-VITRO SUSCEPTIBILITIES; FRAGMENT LENGTH POLYMORPHISM; HEMATOLOGY-ONCOLOGY PATIENTS; ORGAN TRANSPLANT RECIPIENTS; DESORPTION IONIZATION-TIME;},
language = {eng},
issn = {1198-743X},
journal = {Clinical Microbiology and Infection},
title = {ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013},
url = {http://onlinelibrary.wiley.com/doi/10.1111/1469-0691.12371/pdf},
volume = {20},
year = {2014}
}
TY - JOUR
ID - 1198044
AU - Cornely, O.A. - Arikan- Akdagli, S. - Dannaoui, E. - Groll, A.H. - Lagrou, K. - Chakrabarti, A. - Lanternier, F. - Pagano, L. - Skiada, A. - Akova, M. - Arendrup, M.C. - Boekhout, T. - Chowdhary, A. - Cuenca- Estrella, M. - Freiberger, Tomáš - Guinea, J. - Guarro, J. - de Hoog, S. - Hope, W. - Johnson, E. - Kathuria, S. - Lackner, M. - Lass- Flörl, C. - Lortholary, O. - Meis, J.F. - Melatiadis, J. - Munoz, P. - Richardson, M. - Roilides, E. - Tortorano, A.M. - Ullmann, A.J. - van Diepeningen, A. - Verweij, P. - Petrikkos, G.
PY - 2014
TI - ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013
JF - Clinical Microbiology and Infection
VL - 20
IS - April
SP - 5-26
EP - 5-26
PB - Wiley- Blackwell
SN - 1198743X
KW - LIPOSOMAL AMPHOTERICIN-B
KW - INVASIVE FUNGAL-INFECTIONS
KW - ORBITAL-CEREBRAL MUCORMYCOSIS
KW - IN-VITRO SUSCEPTIBILITIES
KW - FRAGMENT LENGTH POLYMORPHISM
KW - HEMATOLOGY-ONCOLOGY PATIENTS
KW - ORGAN TRANSPLANT RECIPIENTS
KW - DESORPTION IONIZATION-TIME;
UR - http://onlinelibrary.wiley.com/doi/10.1111/1469-0691.12371/pdf
L2 - http://onlinelibrary.wiley.com/doi/10.1111/1469-0691.12371/pdf
N2 - These European Society for Clinical Microbiology and Infectious Diseases and European Confederation of Medical Mycology Joint Clinical Guidelines focus on the diagnosis and management of mucormycosis. Only a few of the numerous recommendations can be summarized here. To diagnose mucormycosis, direct microscopy preferably using optical brighteners, histopathology and culture are strongly recommended. Pathogen identification to species level by molecular methods and susceptibility testing are strongly recommended to establish epidemiological knowledge. The recommendation for guiding treatment based on MICs is supported only marginally. Imaging is strongly recommended to determine the extent of disease. To differentiate mucormycosis from aspergillosis in haematological malignancy and stem cell transplantation recipients, identification of the reverse halo sign on computed tomography is advised with moderate strength. For adults and children we strongly recommend surgical debridement in addition to immediate first-line antifungal treatment with liposomal or lipid-complex amphotericin B with a minimum dose of 5mg/kg/day. Amphotericin B deoxycholate is better avoided because of severe adverse effects. For salvage treatment we strongly recommend posaconazole 4x200mg/day. Reversal of predisposing conditions is strongly recommended, i.e. using granulocyte colony-stimulating factor in haematological patients with ongoing neutropenia, controlling hyperglycaemia and ketoacidosis in diabetic patients, and limiting glucocorticosteroids to the minimum dose required. We recommend against using deferasirox in haematological patients outside clinical trials, and marginally support a recommendation for deferasirox in diabetic patients. Hyperbaric oxygen is supported with marginal strength only. Finally, we strongly recommend continuing treatment until complete response demonstrated on imaging and permanent reversal of predisposing factors.
ER -
CORNELY, O.A., S. ARIKAN- AKDAGLI, E. DANNAOUI, A.H. GROLL, K. LAGROU, A. CHAKRABARTI, F. LANTERNIER, L. PAGANO, A. SKIADA, M. AKOVA, M.C. ARENDRUP, T. BOEKHOUT, A. CHOWDHARY, M. CUENCA- ESTRELLA, Tomáš FREIBERGER, J. GUINEA, J. GUARRO, S. DE HOOG, W. HOPE, E. JOHNSON, S. KATHURIA, M. LACKNER, C. LASS- FLÖRL, O. LORTHOLARY, J.F. MEIS, J. MELATIADIS, P. MUNOZ, M. RICHARDSON, E. ROILIDES, A.M. TORTORANO, A.J. ULLMANN, A. VAN DIEPENINGEN, P. VERWEIJ a G. PETRIKKOS. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013. \textit{Clinical Microbiology and Infection}. Hoboken (USA): Wiley- Blackwell, 2014, roč.~20, April, s.~5-26. ISSN~1198-743X. doi:10.1111/1469-0691.12371.
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