Detailed Information on Publication Record
2014
Effect of ethanol on action potential in ventricular cardiomyocytes: experimental and computational approach
PÁSEK, Michal, Markéta BÉBAROVÁ, Georges CHRISTÉ, Milena ŠIMURDOVÁ, Jiří ŠIMURDA et. al.Basic information
Original name
Effect of ethanol on action potential in ventricular cardiomyocytes: experimental and computational approach
Name in Czech
Účinek etanolu na akční napětí u komorových kardiomyocytů: experimentální a výpočtový přístup
Authors
PÁSEK, Michal, Markéta BÉBAROVÁ, Georges CHRISTÉ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA
Edition
Physiology 2014, 2014
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30105 Physiology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Organization unit
Faculty of Medicine
Keywords in English
ethanol; cardiac cell; action potential; rat ventricular cell model; human ventricular cell model
Tags
International impact, Reviewed
Změněno: 17/9/2014 14:38, doc. Ing. Michal Pásek, Ph.D.
Abstract
V originále
In this work, the concentration dependences of ethanol-induced inhibition/activation of ionic currents derived from experimental data were incorporated into the published models of rat and human ventricular cardiomyocyte with the aim to assess the share of ionic current components in ethanol-induced changes of AP configuration. Our results suggest that contribution of individual ionic current components to the effect of ethanol on AP repolarization in cardiac cell is strongly dependent on species differences in current densities. Because AP configuration in the human model shows only a small sensitivity to variations of IK1, the effect of ethanol-induced inhibition of IKr predominates implying prolongation of APD. This effect might contribute to the clinically observed prolongation of QTc interval in ECG under consumption of alcohol.
Links
| NT14301, research and development project |
|