Další formáty:
BibTeX
LaTeX
RIS
@proceedings{1198291, author = {Samadder, Pounami}, booktitle = {Central European DNA Repair Meeting}, keywords = {CHK1 DNA repair cancer}, language = {eng}, title = {Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication}, url = {http://gscd.gmi.oeaw.ac.at/Plone/events/central-european-dna-repair-meeting}, year = {2013} }
TY - CONF ID - 1198291 AU - Samadder, Pounami PY - 2013 TI - Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication KW - CHK1 DNA repair cancer UR - http://gscd.gmi.oeaw.ac.at/Plone/events/central-european-dna-repair-meeting N2 - Complex networks of redundant surveillance mechanisms, namely evolutionarily conserved DNA damage response (DDR) and checkpoints, maintain genomic integrity following various genomic insults. Exploring synthetic lethal interactions between DNA repair pathways have wide appliance to the treatment of many types of malignancies. One of the key players in genome surveillance pathways is a protein kinase, CHK1. DNA damage and replication stress supposedly induces activation of CHK1, which then transduces the checkpoint signal and aids cell cycle arrest allowing time for DNA repair. Hence, CHK1 represents druggable molecular target for inhibition following replication stress induced by chemotherapeutic agents. Such synthetic lethal interaction leads to enhanced sensitivity of cancer cells with additional burden of damaged DNA, without cytotoxic effects to the normal cells. ER -
SAMADDER, Pounami. Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication. In \textit{Central European DNA Repair Meeting}. 2013.
|