BEŠŠE, Lenka, Lenka SEDLAŘÍKOVÁ, Fedor KRYUKOV, Jana NEKVINDOVÁ, Lenka RADOVÁ, Dávid VRÁBEL, Zdeněk ADAM, Luděk POUR, Sabina ŠEVČÍKOVÁ and Roman HÁJEK. CIRCULATING MIR-34a AND MIR-130a AS BIOMARKERS OF EXTRAMEDULLARY DISEASE. In 19th Congress of the European Hematology Association; June 12-15, 2014; Milano, Italy. 2014.
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Basic information
Original name CIRCULATING MIR-34a AND MIR-130a AS BIOMARKERS OF EXTRAMEDULLARY DISEASE
Authors BEŠŠE, Lenka (203 Czech Republic, belonging to the institution), Lenka SEDLAŘÍKOVÁ (203 Czech Republic, belonging to the institution), Fedor KRYUKOV (643 Russian Federation, belonging to the institution), Jana NEKVINDOVÁ (203 Czech Republic), Lenka RADOVÁ (203 Czech Republic), Dávid VRÁBEL (703 Slovakia, belonging to the institution), Zdeněk ADAM (203 Czech Republic), Luděk POUR (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Roman HÁJEK (203 Czech Republic, belonging to the institution).
Edition 19th Congress of the European Hematology Association; June 12-15, 2014; Milano, Italy, 2014.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 30200 3.2 Clinical medicine
Country of publisher Italy
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/14:00076659
Organization unit Faculty of Medicine
Keywords in English Multiple myeloma; Quantitative RT-PCR
Tags EL OK
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 18/12/2014 17:45.
Abstract
MicroRNAs (miRNA), short non-coding regulatory RNAs, are implicated in deregulation of critical pathways involved in multiple myeloma (MM) and extramedullary form of MM (EM). EM is a type of MM defined by the presence of extraskeletal plasma cells (PCs) infiltrates, either related to bone or present in soft tissue. EM Circulating miRNAs are highly stable and are both detectable and quantifiable in a range of accessible bio fluids, thus have the potential to be useful diagnostic biomarkers. We have identified a specific serum miRNA profile in patients with extramedullary disease and correlated it with clinically important parameters.
Links
EE2.3.20.0046, research and development projectName: Mezinárodní centrum pro výzkum a vzdělávání v oblasti hematoonkologie a monoklonálních gamapatií
MUNI/11/InGA17/2012, interní kód MUName: MikroRNA v patogenezi extramedulárního relapsu mnohočetného myelomu
Investor: Masaryk University
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