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@article{1202043,
author = {Uhlík, Jiří and Šimůnková, Petra and Žaloudíková, Marie and Partlová, Simona and Jarkovský, Jiří and Vajner, Luděk},
article_location = {Basel},
article_number = {4},
doi = {http://dx.doi.org/10.1159/000366278},
keywords = {Brown Norway rats; Ovalbumin; Morphometry; Eosinophils; Goblet cells; Basement membrane},
language = {eng},
issn = {1018-2438},
journal = {INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY},
title = {Airway Wall Remodeling in Young and Adult Rats with Experimentally Provoked Bronchial Asthma},
volume = {164},
year = {2014}
}
TY - JOUR
ID - 1202043
AU - Uhlík, Jiří - Šimůnková, Petra - Žaloudíková, Marie - Partlová, Simona - Jarkovský, Jiří - Vajner, Luděk
PY - 2014
TI - Airway Wall Remodeling in Young and Adult Rats with Experimentally Provoked Bronchial Asthma
JF - INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
VL - 164
IS - 4
SP - 289-300
EP - 289-300
PB - Karger
SN - 10182438
KW - Brown Norway rats
KW - Ovalbumin
KW - Morphometry
KW - Eosinophils
KW - Goblet cells
KW - Basement membrane
N2 - Background: Airway wall remodeling is a typical finding in patients suffering from bronchial asthma. While morphological changes have been thoroughly described in adults, less is known about such changes in children because of the limited accessibility of relevant material. To overcome this constraint, animal asthma models may be used instead of human specimens. This study examined rats with artificially stimulated chronic asthma-like symptoms. Methods: Brown Norway rats of two age categories (young and adult) were sensitized by ovalbumin (OA), and their intrapulmonary airways (IA) were studied using morphometric and histochemical methods. Results: OA administration induced a significant increase in lung resistance in young animals but not in adults. The total IA wall area was significantly increased in both young and adult OA rats. In young animals, thickening of the adventitia played a more crucial role in this increase than it did in adults, in which the mucosa and the submucosa participated to a higher degree. The IA walls of young OA rats had significantly higher levels of infiltrating eosinophils than those of adult OA animals. The multiplication of goblet cells was more pronounced in adult rats, which was associated with a tendency to produce a higher proportion of acidic glycoconjugates. Conclusions: OA stimulation affected the IA of young rats differently than those of adult animals. Changes in the outer IA layer of young rats can be triggered by activated eosinophils; however, stimulated airway epithelium can be a source of factors that influence the inner IA layers in adult rats.
ER -
UHLÍK, Jiří, Petra ŠIMŮNKOVÁ, Marie ŽALOUDÍKOVÁ, Simona PARTLOVÁ, Jiří JARKOVSKÝ a Luděk VAJNER. Airway Wall Remodeling in Young and Adult Rats with Experimentally Provoked Bronchial Asthma. Online. \textit{INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY}. Basel: Karger, 2014, roč.~164, č.~4, s.~289-300. ISSN~1018-2438. Dostupné z: https://dx.doi.org/10.1159/000366278. [citováno 2024-04-24]
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