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@article{1202118,
author = {Narzo, Antonio Fabio Di and Tejpar, Sabine and Rossi, Simona and Yan, Pu and Popovici, Vlad and Wirapati, Pratyaksha and Budinská, Eva and Xie, Tao and Estrella, Heather and Pavlicek, Adam and Mao, Mao and Eric, Martin and Scott, Weinrich and Bosman, Fred T and Roth, Arnaud and Delorenzi, Mauro},
article_location = {Bethesda},
article_number = {10},
doi = {http://dx.doi.org/10.1093/jnci/dju247},
keywords = {colon cancer; microarray; gene expression; prognostic signature},
language = {eng},
issn = {0027-8874},
journal = {Journal of the National Cancer Institute},
title = {Test of Four Colon Cancer Risk-Scores in Formalin Fixed Paraffin Embedded Microarray Gene Expression Data},
volume = {106},
year = {2014}
}
TY - JOUR
ID - 1202118
AU - Narzo, Antonio Fabio Di - Tejpar, Sabine - Rossi, Simona - Yan, Pu - Popovici, Vlad - Wirapati, Pratyaksha - Budinská, Eva - Xie, Tao - Estrella, Heather - Pavlicek, Adam - Mao, Mao - Eric, Martin - Scott, Weinrich - Bosman, Fred T - Roth, Arnaud - Delorenzi, Mauro
PY - 2014
TI - Test of Four Colon Cancer Risk-Scores in Formalin Fixed Paraffin Embedded Microarray Gene Expression Data
JF - Journal of the National Cancer Institute
VL - 106
IS - 10
SP - 1-8
EP - 1-8
PB - National Cancer Institute
SN - 00278874
KW - colon cancer
KW - microarray
KW - gene expression
KW - prognostic signature
N2 - Background Prognosis prediction for resected primary colon cancer is based on the T-stage Node Metastasis (TNM) staging system. We investigated if four well-documented gene expression risk scores can improve patient stratification.Methods Microarray-based versions of risk-scores were applied to a large independent cohort of 688 stage II/III tumors from the PETACC-3 trial. Prognostic value for relapse-free survival (RFS), survival after relapse (SAR), and overall survival (OS) was assessed by regression analysis. To assess improvement over a reference, prognostic model was assessed with the area under curve (AUC) of receiver operating characteristic (ROC) curves. All statistical tests were two-sided, except the AUC increase.Results All four risk scores (RSs) showed a statistically significant association (single-test, P < .0167) with OS or RFS in univariate models, but with HRs below 1.38 per interquartile range. Three scores were predictors of shorter RFS, one of shorter SAR. Each RS could only marginally improve an RFS or OS model with the known factors T-stage, N-stage, and microsatellite instability (MSI) status (AUC gains < 0.025 units). The pairwise interscore discordance was never high (maximal Spearman correlation = 0.563) A combined score showed a trend to higher prognostic value and higher AUC increase for OS (HR = 1.74, 95% confidence interval [CI] = 1.44 to 2.10, P < .001, AUC from 0.6918 to 0.7321) and RFS (HR = 1.56, 95% CI = 1.33 to 1.84, P < .001, AUC from 0.6723 to 0.6945) than any single score.Conclusions The four tested gene expression–based risk scores provide prognostic information but contribute only marginally to improving models based on established risk factors. A combination of the risk scores might provide more robust information. Predictors of RFS and SAR might need to be different.
ER -
NARZO, Antonio Fabio Di, Sabine TEJPAR, Simona ROSSI, Pu YAN, Vlad POPOVICI, Pratyaksha WIRAPATI, Eva BUDINSKÁ, Tao XIE, Heather ESTRELLA, Adam PAVLICEK, Mao MAO, Martin ERIC, Weinrich SCOTT, Fred T BOSMAN, Arnaud ROTH and Mauro DELORENZI. Test of Four Colon Cancer Risk-Scores in Formalin Fixed Paraffin Embedded Microarray Gene Expression Data. \textit{Journal of the National Cancer Institute}. Bethesda: National Cancer Institute, 2014, vol.~106, No~10, p.~1-8. ISSN~0027-8874. Available from: https://dx.doi.org/10.1093/jnci/dju247.
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