SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER
POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN
VENTRICULAR CARDIOMYOCYTES

D 2014

SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES

PÁSEK, Michal, Jiří ŠIMURDA and G. CHRISTÉ

Basic information

Original name

SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES

Authors

PÁSEK, Michal (203 Czech Republic, guarantor, belonging to the institution), Jiří ŠIMURDA (203 Czech Republic, belonging to the institution) and G. CHRISTÉ (250 France)

Edition

Brno, Engineering Mechanics 2014, p. 476-479, 4 pp. 2014

Publisher

University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

RIV identification code

RIV/00216224:14110/14:00080145

Organization unit

Faculty of Medicine

ISBN

978-80-214-4871-1

ISSN

Keywords in English

Cardiac cell; Action potential; Inward rectifier potassium current; Quantitative modelling

Abstract

V originále

The inwardly rectifying potassium current IK1 is one of the principle ionic currents responsible for repolarization phase of mammalian action potentials (APs). To estimate the impact of individual ionic currents on AP configuration, mathematical models have been widely used. In this study, we compare the effects of alcohol-induced changes of IK1 on AP duration (APD) as simulated in four recently published computer models of human ventricular cells. As expected, increasing or decreasing IK1 conductance by 20% respectively caused a shortening or a lengthening of APD. However, the effect was largely model-dependent, ranging from 1% to about 15% change of APD. Given the conflicting available experimental data on the features of IK1 in human ventricular myocytes there is a need for a set of well-established end-point constraints for a reliable human ventricular myocyte model to be generated.

Links

NT14301, research and development project

Name: Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?

Investor: Ministry of Health of the CR

Citovat

PÁSEK, Michal, Jiří ŠIMURDA and G. CHRISTÉ. SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES. In Vladimír Fuis. Engineering Mechanics 2014. Brno: University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics, 2014, p. 476-479. ISBN 978-80-214-4871-1.

@inproceedings{1202671,
   author = {Pásek, Michal and Šimurda, Jiří and Christé, G.},
   address = {Brno},
   booktitle = {Engineering Mechanics 2014},
   editor = {Vladimír Fuis},
   keywords = {Cardiac cell; Action potential; Inward rectifier potassium current; Quantitative modelling},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Brno},
   isbn = {978-80-214-4871-1},
   pages = {476-479},
   publisher = {University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics},
   title = {SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES},
   year = {2014}
}

TY  - JOUR
ID  - 1202671
AU  - Pásek, Michal - Šimurda, Jiří - Christé, G.
PY  - 2014
TI  - SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES
PB  - University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics
CY  - Brno
SN  - 9788021448711
KW  - Cardiac cell
KW  - Action potential
KW  - Inward rectifier potassium current
KW  - Quantitative modelling
N2  - The inwardly rectifying potassium current IK1 is one of the principle ionic currents responsible for repolarization phase of mammalian action potentials (APs). To estimate the impact of individual ionic currents on AP configuration, mathematical models have been widely used. In this study, we compare the effects of alcohol-induced changes of IK1 on AP duration (APD) as simulated in four recently published computer models of human ventricular cells. As expected, increasing or decreasing IK1 conductance by 20% respectively caused a shortening or a lengthening of APD. However, the effect was largely model-dependent, ranging from 1% to about 15% change of APD. Given the conflicting available experimental data on the features of IK1 in human ventricular myocytes there is a need for a set of well-established end-point constraints for a reliable human ventricular myocyte model to be generated.
ER  -

PÁSEK, Michal, Jiří ŠIMURDA and G. CHRISTÉ. SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES. In Vladimír Fuis. \textit{Engineering Mechanics 2014}. Brno: University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics, 2014, p.~476-479. ISBN~978-80-214-4871-1.

Detailed Information on Publication Record