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@article{1202751,
author = {Holčáková, Jitka and Češková, Pavla and Hrstka, Roman and Müller, Petr and Zdražilová Dubská, Lenka and Coates, Philip J and Paleček, Emil and Vojtěšek, Bořivoj},
article_number = {3},
doi = {http://dx.doi.org/10.2478/s11658-008-0011-z},
journal = {CELLULAR & MOLECULAR BIOLOGY LETTERS},
title = {The cell type-specific effect of TAp73 isoforms on the cell cycle and apoptosis},
volume = {13},
year = {2008}
}
TY - JOUR
ID - 1202751
AU - Holčáková, Jitka - Češková, Pavla - Hrstka, Roman - Müller, Petr - Zdražilová Dubská, Lenka - Coates, Philip J - Paleček, Emil - Vojtěšek, Bořivoj
PY - 2008
TI - The cell type-specific effect of TAp73 isoforms on the cell cycle and apoptosis
JF - CELLULAR & MOLECULAR BIOLOGY LETTERS
VL - 13
IS - 3
SP - 404-420
EP - 404-420
N2 - p73, a member of the p53 family, exhibits activities similar to those of p53, including the ability to induce growth arrest and apoptosis. p73 influences chemotherapeutic responses in human cancer patients, in association with p53. Alternative splicing of the TP73 gene produces many p73 C- and N-terminal isoforms, which vary in their transcriptional activity towards p53-responsive promoters. In this paper, we show that the C-terminal spliced isoforms of the p73 protein differ in their DNA-binding capacity, but this is not an accurate predictor of transcriptional activity. In different p53-null cell lines, p73 beta induces either mitochondrial-associated or death receptor-mediated apoptosis, and these differences are reflected in different gene expression profiles. In addition, p73 induces cell cycle arrest and p21(WAF1) expression in H1299 cells, but not in Saos-2. This data shows that TAp73 isoforms act differently depending on the tumour cell background, and have important implications for p73-mediated therapeutic responses in individual human cancer patients.
ER -
HOLČÁKOVÁ, Jitka, Pavla ČEŠKOVÁ, Roman HRSTKA, Petr MÜLLER, Lenka ZDRAŽILOVÁ DUBSKÁ, Philip J COATES, Emil PALEČEK a Bořivoj VOJTĚŠEK. The cell type-specific effect of TAp73 isoforms on the cell cycle and apoptosis. Online. \textit{CELLULAR \&{}amp; MOLECULAR BIOLOGY LETTERS}. 2008, roč.~13, č.~3, s.~404-420. Dostupné z: https://dx.doi.org/10.2478/s11658-008-0011-z. [citováno 2024-04-23]
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