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@article{1202841,
author = {Ručka, Zdeněk and Krontorád Koutná, Irena and Tesařová, Lenka and Potěšilová, Michaela and Stejskal, Stanislav and Šimara, Pavel and Vaňhara, Petr and Doležel, Jan and Zvoníček, Václav and Coufal, Oldřich and Čapov, Ivan},
article_location = {London, United Kingdom},
article_number = {1},
doi = {http://dx.doi.org/10.1186/1471-2466-14-155},
keywords = {surfactant proteins; insulin therapy},
language = {eng},
issn = {1471-2466},
journal = {BMC Pulmonary Medicine},
title = {Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins},
volume = {14},
year = {2014}
}
TY - JOUR
ID - 1202841
AU - Ručka, Zdeněk - Krontorád Koutná, Irena - Tesařová, Lenka - Potěšilová, Michaela - Stejskal, Stanislav - Šimara, Pavel - Vaňhara, Petr - Doležel, Jan - Zvoníček, Václav - Coufal, Oldřich - Čapov, Ivan
PY - 2014
TI - Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins
JF - BMC Pulmonary Medicine
VL - 14
IS - 1
SP - 155-163
EP - 155-163
PB - BIOMED CENTRAL LTD
SN - 14712466
KW - surfactant proteins
KW - insulin therapy
N2 - The surgical resection of lung disrupts glucose homeostasis and causes hyperglycemia, as in any other major surgery or critical illness. We performed a prospective study where we carefully lowered hyperglycemia by insulin administration during the surgery, and for the first time we monitored immediate insulin effects on lung physiology and gene transcription.The levels of blood gases (pH, pCO2, pO2, HCO3-, HCO3- std, base excess, FiO2, and pO2/FiO2) were measured at the beginning of surgery, at the end of surgery, and two hours after. Samples of healthy lung tissue surrounding the tumour were obtained during the surgery, anonymized and sent for subsequent blinded qPCR analysis (mRNA levels of surfactant proteins A1, A2, B, C and D were measured). This study was done on a cohort of 64 patients who underwent lung resection. Patients were randomly divided, and half of them received insulin treatment during the surgery.We demonstrated for the first time that insulin administered intravenously during lung resection does not affect levels of blood gases. Furthermore, it does not induce immediate changes in the expression of surfactant proteins.According to our observations, short insulin treatment applied intravenously during resection does not affect the quality of breathing.
ER -
RUČKA, Zdeněk, Irena KRONTORÁD KOUTNÁ, Lenka TESAŘOVÁ, Michaela POTĚŠILOVÁ, Stanislav STEJSKAL, Pavel ŠIMARA, Petr VAŇHARA, Jan DOLEŽEL, Václav ZVONÍČEK, Oldřich COUFAL and Ivan ČAPOV. Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins. \textit{BMC Pulmonary Medicine}. London, United Kingdom: BIOMED CENTRAL LTD, 2014, vol.~14, No~1, p.~155-163. ISSN~1471-2466. Available from: https://dx.doi.org/10.1186/1471-2466-14-155.
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