Intravenous insulin therapy during lung resection does not
affect lung function or surfactant  proteins

J 2014

Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins

RUČKA, Zdeněk, Irena KRONTORÁD KOUTNÁ, Lenka TESAŘOVÁ, Michaela POTĚŠILOVÁ, Stanislav STEJSKAL et. al.

Basic information

Original name

Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins

Authors

RUČKA, Zdeněk (203 Czech Republic, belonging to the institution), Irena KRONTORÁD KOUTNÁ (203 Czech Republic, guarantor, belonging to the institution), Lenka TESAŘOVÁ (203 Czech Republic, belonging to the institution), Michaela POTĚŠILOVÁ (203 Czech Republic, belonging to the institution), Stanislav STEJSKAL (203 Czech Republic, belonging to the institution), Pavel ŠIMARA (203 Czech Republic, belonging to the institution), Petr VAŇHARA (203 Czech Republic, belonging to the institution), Jan DOLEŽEL (203 Czech Republic), Václav ZVONÍČEK (203 Czech Republic), Oldřich COUFAL (203 Czech Republic) and Ivan ČAPOV (203 Czech Republic)

Edition

BMC Pulmonary Medicine, London, United Kingdom, BIOMED CENTRAL LTD, 2014, 1471-2466

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30203 Respiratory systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.404

RIV identification code

RIV/00216224:14330/14:00073971

Organization unit

Faculty of Informatics

DOI

http://dx.doi.org/10.1186/1471-2466-14-155

UT WoS

000346666500001

Keywords in English

surfactant proteins; insulin therapy

Abstract

V originále

The surgical resection of lung disrupts glucose homeostasis and causes hyperglycemia, as in any other major surgery or critical illness. We performed a prospective study where we carefully lowered hyperglycemia by insulin administration during the surgery, and for the first time we monitored immediate insulin effects on lung physiology and gene transcription.The levels of blood gases (pH, pCO2, pO2, HCO3-, HCO3- std, base excess, FiO2, and pO2/FiO2) were measured at the beginning of surgery, at the end of surgery, and two hours after. Samples of healthy lung tissue surrounding the tumour were obtained during the surgery, anonymized and sent for subsequent blinded qPCR analysis (mRNA levels of surfactant proteins A1, A2, B, C and D were measured). This study was done on a cohort of 64 patients who underwent lung resection. Patients were randomly divided, and half of them received insulin treatment during the surgery.We demonstrated for the first time that insulin administered intravenously during lung resection does not affect levels of blood gases. Furthermore, it does not induce immediate changes in the expression of surfactant proteins.According to our observations, short insulin treatment applied intravenously during resection does not affect the quality of breathing.

Links

CZ.1.07/2.3.00/30.0030, interní kód MU

Name: Rozvoj lidských zdrojů pro oblast buněčné biologie

Investor: Ministry of Education, Youth and Sports of the CR, 2.3 Human resources in research and development

GBP302/12/G157, research and development project

Name: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii

Investor: Czech Science Foundation

Citovat

RUČKA, Zdeněk, Irena KRONTORÁD KOUTNÁ, Lenka TESAŘOVÁ, Michaela POTĚŠILOVÁ, Stanislav STEJSKAL, Pavel ŠIMARA, Petr VAŇHARA, Jan DOLEŽEL, Václav ZVONÍČEK, Oldřich COUFAL and Ivan ČAPOV. Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins. BMC Pulmonary Medicine. London, United Kingdom: BIOMED CENTRAL LTD, 2014, vol. 14, No 1, p. 155-163. ISSN 1471-2466. Available from: https://dx.doi.org/10.1186/1471-2466-14-155.

@article{1202841,
   author = {Ručka, Zdeněk and Krontorád Koutná, Irena and Tesařová, Lenka and Potěšilová, Michaela and Stejskal, Stanislav and Šimara, Pavel and Vaňhara, Petr and Doležel, Jan and Zvoníček, Václav and Coufal, Oldřich and Čapov, Ivan},
   article_location = {London, United Kingdom},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/1471-2466-14-155},
   keywords = {surfactant proteins; insulin therapy},
   language = {eng},
   issn = {1471-2466},
   journal = {BMC Pulmonary Medicine},
   title = {Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins},
   volume = {14},
   year = {2014}
}

TY  - JOUR
ID  - 1202841
AU  - Ručka, Zdeněk - Krontorád Koutná, Irena - Tesařová, Lenka - Potěšilová, Michaela - Stejskal, Stanislav - Šimara, Pavel - Vaňhara, Petr - Doležel, Jan - Zvoníček, Václav - Coufal, Oldřich - Čapov, Ivan
PY  - 2014
TI  - Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins
JF  - BMC Pulmonary Medicine
VL  - 14
IS  - 1
SP  - 155-163
EP  - 155-163
PB  - BIOMED CENTRAL LTD
SN  - 14712466
KW  - surfactant proteins
KW  - insulin therapy
N2  - The surgical resection of lung disrupts glucose homeostasis and causes hyperglycemia, as in any other major surgery or critical illness. We performed a prospective study where we carefully lowered hyperglycemia by insulin administration during the surgery, and for the first time we monitored immediate insulin effects on lung physiology and gene transcription.The levels of blood gases (pH, pCO2, pO2, HCO3-, HCO3- std, base excess, FiO2, and pO2/FiO2) were measured at the beginning of surgery, at the end of surgery, and two hours after. Samples of healthy lung tissue surrounding the tumour were obtained during the surgery, anonymized and sent for subsequent blinded qPCR analysis (mRNA levels of surfactant proteins A1, A2, B, C and D were measured). This study was done on a cohort of 64 patients who underwent lung resection. Patients were randomly divided, and half of them received insulin treatment during the surgery.We demonstrated for the first time that insulin administered intravenously during lung resection does not affect levels of blood gases. Furthermore, it does not induce immediate changes in the expression of surfactant proteins.According to our observations, short insulin treatment applied intravenously during resection does not affect the quality of breathing.
ER  -

RUČKA, Zdeněk, Irena KRONTORÁD KOUTNÁ, Lenka TESAŘOVÁ, Michaela POTĚŠILOVÁ, Stanislav STEJSKAL, Pavel ŠIMARA, Petr VAŇHARA, Jan DOLEŽEL, Václav ZVONÍČEK, Oldřich COUFAL and Ivan ČAPOV. Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins. \textit{BMC Pulmonary Medicine}. London, United Kingdom: BIOMED CENTRAL LTD, 2014, vol.~14, No~1, p.~155-163. ISSN~1471-2466. Available from: https://dx.doi.org/10.1186/1471-2466-14-155.

Detailed Information on Publication Record