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@inproceedings{1204439,
author = {Turjap, Miroslav and Dovrtělová, Gabriela and Nosková, Kristýna and Zendulka, Ondřej and Juřica, Jan},
address = {Brno},
booktitle = {CECE 2014: 11TH INTERNATIONAL INTERDISCIPLINARY MEETING ON BIOANALYSIS},
editor = {František Foret, Jana Křenková, Iveta Drobníková, Andras Guttman, Karel Klepárník},
keywords = {LIQUID-CHROMATOGRAPHY},
howpublished = {elektronická verze "online"},
language = {eng},
location = {Brno},
isbn = {978-80-904959-2-0},
pages = {270-273},
publisher = {Institute of Analytical Chemistry AS CR},
title = {DETERMINATION OF TESTOSTERONE AND ITS 5 METABOLITES IN THE INCUBATION MEDIA AS A MEASURE OF CYTOCHROME P450 METABOLIC ACTIVITY},
year = {2014}
}
TY - JOUR
ID - 1204439
AU - Turjap, Miroslav - Dovrtělová, Gabriela - Nosková, Kristýna - Zendulka, Ondřej - Juřica, Jan
PY - 2014
TI - DETERMINATION OF TESTOSTERONE AND ITS 5 METABOLITES IN THE INCUBATION MEDIA AS A MEASURE OF CYTOCHROME P450 METABOLIC ACTIVITY
PB - Institute of Analytical Chemistry AS CR
CY - Brno
SN - 9788090495920
KW - LIQUID-CHROMATOGRAPHY
N2 - The innovative HPLC method for the determination of testosterone and its five metabolites in incubation medium with rat liver microsomes is reported. The method utilizes liquid-liquid extraction procedure, with use of internal standard prednisone. Analytes are eluted within 18.7 min. The method enables reliable determination of testosterone, 7 alpha-hydroxytestosterone, 6 beta-hydroxytestosterone, 16 alpha-hydroxytestosterone, 16 beta-hydroxytestosterone, 2 beta-hydroxytestosterone with LOD in the range 1.9-3.9 nmol/L.
ER -
TURJAP, Miroslav, Gabriela DOVRTĚLOVÁ, Kristýna NOSKOVÁ, Ondřej ZENDULKA and Jan JUŘICA. DETERMINATION OF TESTOSTERONE AND ITS 5 METABOLITES IN THE INCUBATION MEDIA AS A MEASURE OF CYTOCHROME P450 METABOLIC ACTIVITY. Online. In František Foret, Jana Křenková, Iveta Drobníková, Andras Guttman, Karel Klepárník. \textit{CECE 2014: 11TH INTERNATIONAL INTERDISCIPLINARY MEETING ON BIOANALYSIS}. Brno: Institute of Analytical Chemistry AS CR, 2014, p.~270-273. ISBN~978-80-904959-2-0.
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