| SARANGI, Prabha, Veronika ALTMANNOVÁ, Cory HOLLAND, Zdenka BARTOŠOVÁ, Fanfan HAO, Dorothea ANRATHER, Gustav AMMERER, Sang Eun LEE, Lumír KREJČÍ and Xiaolan ZHAO. A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions. Cell Reports. CAMBRIDGE, Spojené státy americké: Cell Press, 2014, vol. 9, No 1, p. 143-152. ISSN 2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2014.08.054. |
Other formats:
BibTeX
LaTeX
RIS
@article{1204451,
author = {Sarangi, Prabha and Altmannová, Veronika and Holland, Cory and Bartošová, Zdenka and Hao, Fanfan and Anrather, Dorothea and Ammerer, Gustav and Lee, Sang Eun and Krejčí, Lumír and Zhao, Xiaolan},
article_location = {CAMBRIDGE, Spojené státy americké},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.celrep.2014.08.054},
keywords = {STRAND BREAK REPAIR; YEAST SCHIZOSACCHAROMYCES-POMBE; HOLLIDAY JUNCTION RESOLVASE; DNA-REPAIR; SACCHAROMYCES-CEREVISIAE; PROTEIN INTERACTIONS; RAD1-RAD10 NUCLEASE; ABASIC SITES; RECOMBINATION; ENDONUCLEASE},
language = {eng},
issn = {2211-1247},
journal = {Cell Reports},
title = {A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions},
volume = {9},
year = {2014}
}
TY - JOUR
ID - 1204451
AU - Sarangi, Prabha - Altmannová, Veronika - Holland, Cory - Bartošová, Zdenka - Hao, Fanfan - Anrather, Dorothea - Ammerer, Gustav - Lee, Sang Eun - Krejčí, Lumír - Zhao, Xiaolan
PY - 2014
TI - A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions
JF - Cell Reports
VL - 9
IS - 1
SP - 143-152
EP - 143-152
PB - Cell Press
SN - 22111247
KW - STRAND BREAK REPAIR
KW - YEAST SCHIZOSACCHAROMYCES-POMBE
KW - HOLLIDAY JUNCTION RESOLVASE
KW - DNA-REPAIR
KW - SACCHAROMYCES-CEREVISIAE
KW - PROTEIN INTERACTIONS
KW - RAD1-RAD10 NUCLEASE
KW - ABASIC SITES
KW - RECOMBINATION
KW - ENDONUCLEASE
N2 - DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show that the budding yeast Saw1 scaffold is more versatile. It helps cells cope with base lesions and protein-DNA adducts through its known function of recruiting the Rad1-Rad10 nuclease to DNA. In addition, it promotes UV survival via a mechanism mediated by its sumoylation. Saw1 sumoylation favors its interaction with another nuclease Slx1-Slx4, and this SUMO-mediated role is genetically separable from two main UV lesion repair processes. These effects of Saw1 and its sumoylation suggest that Saw1 is a multifunctional scaffold that can facilitate diverse types of DNA repair through its modification and nuclease interactions.
ER -
SARANGI, Prabha, Veronika ALTMANNOVÁ, Cory HOLLAND, Zdenka BARTOŠOVÁ, Fanfan HAO, Dorothea ANRATHER, Gustav AMMERER, Sang Eun LEE, Lumír KREJČÍ and Xiaolan ZHAO. A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions. \textit{Cell Reports}. CAMBRIDGE, Spojené státy americké: Cell Press, 2014, vol.~9, No~1, p.~143-152. ISSN~2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2014.08.054.
|
