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@article{1204565, author = {OrtizanddeandSolórzano, Carlos and MuñozandBarrutia, Arrate and Meijering, Erik and Kozubek, Michal}, article_location = {New York}, article_number = {1}, doi = {http://dx.doi.org/10.1109/MSP.2014.2358263}, keywords = {cell model; image segmentation; cell tracking; cell synthesis}, language = {eng}, issn = {1053-5888}, journal = {IEEE Signal Processing Magazine}, title = {Toward a Morphodynamic Model of the Cell}, volume = {32}, year = {2015} }
TY - JOUR ID - 1204565 AU - Ortiz-de-Solórzano, Carlos - Muñoz-Barrutia, Arrate - Meijering, Erik - Kozubek, Michal PY - 2015 TI - Toward a Morphodynamic Model of the Cell JF - IEEE Signal Processing Magazine VL - 32 IS - 1 SP - 20-29 EP - 20-29 PB - IEEE SN - 10535888 KW - cell model KW - image segmentation KW - cell tracking KW - cell synthesis N2 - From a systems biology perspective, the cell is the principal element of information integration. Therefore, understanding the cell in its spatio-temporal context is the key to unraveling many of the still unknown mechanisms of life and disease. The purpose of this manuscript is to review image-processing aspects relevant to the quantification of cell morphology and dynamics. We cover both acquisition (hardware) and analysis (software) related issues, in a multi-scale fashion, from the detection of cellular components to the description of the entire cell in relation to its extracellular environment. Then, we describe ongoing efforts to integrate all this vast and diverse information along with data about the biomechanics of the cell, to create a credible model of cell morphology and behavior. ER -
ORTIZ-DE-SOLÓRZANO, Carlos, Arrate MUÑOZ-BARRUTIA, Erik MEIJERING and Michal KOZUBEK. Toward a Morphodynamic Model of the Cell. \textit{IEEE Signal Processing Magazine}. New York: IEEE, 2015, vol.~32, No~1, p.~20-29. ISSN~1053-5888. Available from: https://dx.doi.org/10.1109/MSP.2014.2358263.
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