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@article{1204945,
author = {Stejskal, Stanislav and Tesařová, Lenka and Krontorád Koutná, Irena},
article_number = {2014},
keywords = {H3K56ac;p300;CBP; pluripotency; chromatin},
language = {eng},
issn = {0015-5500},
journal = {Folia biologica},
title = {Mysterious Role of H3K56ac in Embryonic Stem Cells},
volume = {60},
year = {2014}
}
TY - JOUR
ID - 1204945
AU - Stejskal, Stanislav - Tesařová, Lenka - Krontorád Koutná, Irena
PY - 2014
TI - Mysterious Role of H3K56ac in Embryonic Stem Cells
JF - Folia biologica
VL - 60
IS - 2014
SP - 71-75
EP - 71-75
PB - Univerzita Karlova
SN - 00155500
KW - H3K56ac;p300;CBP
KW - pluripotency
KW - chromatin
N2 - Posttranslational modifications of histones belong to epigenetic mechanisms that regulate gene expression by chromatin structure changes. Generally, histone acetylation reduces its positive charge and consequently weakens the stability of the nucleosome. Acetylation of lysine 56 on histone H3 is implicated in the processes associated with loosened chromatin structure. H3K56ac is a mark for histones with high nucleosome turnover in the nuclear processes such as gene transcription, DNA replication and reparation in yeasts. During evolution, the main H3K56ac regulatory pathway was lost and the level of H3K56ac remained very low in mammalian cells. Moreover, the function of this modification still re- mains unclear. In this minireview, we summarize the recent knowledge of the ambiguous role of H3K56ac in mammalian embryonic stem cells.
ER -
STEJSKAL, Stanislav, Lenka TESAŘOVÁ and Irena KRONTORÁD KOUTNÁ. Mysterious Role of H3K56ac in Embryonic Stem Cells. \textit{Folia biologica}. Univerzita Karlova, 2014, vol.~60, No~2014, p.~71-75. ISSN~0015-5500.
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