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@proceedings{1205105,
author = {Michalcová, Lenka and Glatz, Zdeněk},
booktitle = {CEITEC Annual Conference: "Frontiers in Material and Life Sciences"},
keywords = {capillary electrophoresis, sulfonylurea, binding constant},
language = {eng},
isbn = {978-80-210-7159-9},
title = {Determination of binding constants of selected sulfonylureas drugs},
year = {2014}
}
TY - CONF
ID - 1205105
AU - Michalcová, Lenka - Glatz, Zdeněk
PY - 2014
TI - Determination of binding constants of selected sulfonylureas drugs
SN - 9788021071599
KW - capillary electrophoresis, sulfonylurea, binding constant
N2 - The strength of the interaction has a significant effect on biological activity of the drug. Various sulfonylureas (antidiabetic drugs) may induce hypoglycemia as a result of excesses in insulin production and release. Therefore, it is important to understand in detail the pharmacokinetics and pharmacodynamics of these drugs. The main objectives of this study were to determine the binding constants of the selected sulfonylurea drug (tolbutamide, chlorpropamide) with HSA using capillary electrophoresis – in physiological conditions.
ER -
MICHALCOVÁ, Lenka a Zdeněk GLATZ. Determination of binding constants of selected sulfonylureas drugs. In \textit{CEITEC Annual Conference: ''Frontiers in Material and Life Sciences''}. ISBN~978-80-210-7159-9. 2014.
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