Bacteriocin-encoding genes and ExPEC virulence determinants are
associated in human fecal Escherichia coli strains

J 2014

Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains

MICENKOVÁ, Lenka; Barbora ŠTAUDOVÁ; Juraj BOSÁK; Lenka MIKALOVÁ; Simona LITTNEROVÁ et. al.

Základní údaje

Originální název

Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains

Autoři

MICENKOVÁ, Lenka (703 Slovensko, domácí); Barbora ŠTAUDOVÁ (203 Česká republika, domácí); Juraj BOSÁK (703 Slovensko, domácí); Lenka MIKALOVÁ (203 Česká republika, domácí); Simona LITTNEROVÁ (203 Česká republika, domácí); Martin VRBA (203 Česká republika); Alena ŠEVČÍKOVÁ (203 Česká republika); Vladana WOZNICOVÁ (203 Česká republika, domácí) a David ŠMAJS (203 Česká republika, garant, domácí)

Vydání

BMC Microbiology, LONDON, BioMed Central, 2014, 1471-2180

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.729

Kód RIV

RIV/00216224:14110/14:00080149

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1186/1471-2180-14-109

UT WoS

000335416800002

EID Scopus

2-s2.0-84900446034

Klíčová slova anglicky

Escherichia coli; Colicin; Microcin; Bacteriocin; Virulence factor

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 3. 2025 14:12, Mgr. Tereza Miškechová

Anotace

V originále

Background: A set of 1181 E. coli strains of human fecal origin isolated in the South Moravia region of the Czech Republic was collected during the years 2007-2010. Altogether, 17 virulence determinants and 31 bacteriocin-encoding genes were tested in each of them. Results: The occurrence of bacteriocin-encoding genes was found to be positively correlated with the occurrence of E. coli virulence factors. Based on the presence of virulence factors and their combinations, E. coli strains were classified as non-pathogenic E. coli (n = 399), diarrhea-associated E. coli (n = 179) and ExPEC strains (n = 603). Non-pathogenic and diarrhea-associated E. coli strains had a low frequency of bacteriocinogeny (32.6% and 36.9%, respectively). ExPEC strains encoding S-fimbriae (sfa), P-fimbriae (pap) and having genes for aerobactin biosynthesis (aer, iucC), alpha-hemolysis (alpha-hly) and cytotoxic necrosis factor (cnf1) were often bacteriocinogenic (73.8%), had a high prevalence of bacteriocin multi-producers and showed a higher frequency of genes encoding microcins H47, M, V, B17 and colicins E1, Ia and S4. Conclusions: The occurrence of bacteriocin-encoding genes and ExPEC virulence determinants correlate positively in E. coli strains of human fecal origin. Bacteriocin synthesis appears to modulate the ability of E. coli strains to reside in the human intestine and/or the virulence of the corresponding strains.

Návaznosti

NT13413, projekt VaV

Název: Stanovení apoptózy v biopticky odebraných vzorcích z tlustého střeva

Investor: Ministerstvo zdravotnictví ČR, Stanovení apoptózy v biopticky odebraných vzorcích z tlustého střeva

Citovat

MICENKOVÁ, Lenka; Barbora ŠTAUDOVÁ; Juraj BOSÁK; Lenka MIKALOVÁ; Simona LITTNEROVÁ; Martin VRBA; Alena ŠEVČÍKOVÁ; Vladana WOZNICOVÁ a David ŠMAJS. Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains. BMC Microbiology. LONDON: BioMed Central, 2014, roč. 14, č. 109, s. 1-9. ISSN 1471-2180. Dostupné z: https://doi.org/10.1186/1471-2180-14-109.

@article{1205555,
   author = {Micenková, Lenka and Štaudová, Barbora and Bosák, Juraj and Mikalová, Lenka and Littnerová, Simona and Vrba, Martin and Ševčíková, Alena and Woznicová, Vladana and Šmajs, David},
   article_location = {LONDON},
   article_number = {109},
   doi = {https://doi.org/10.1186/1471-2180-14-109},
   keywords = {Escherichia coli; Colicin; Microcin; Bacteriocin; Virulence factor},
   language = {eng},
   issn = {1471-2180},
   journal = {BMC Microbiology},
   title = {Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains},
   url = {https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-14-109},
   volume = {14},
   year = {2014}
}

TY  - JOUR
ID  - 1205555
AU  - Micenková, Lenka - Štaudová, Barbora - Bosák, Juraj - Mikalová, Lenka - Littnerová, Simona - Vrba, Martin - Ševčíková, Alena - Woznicová, Vladana - Šmajs, David
PY  - 2014
TI  - Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains
JF  - BMC Microbiology
VL  - 14
IS  - 109
SP  - 1-9
EP  - 1-9
PB  - BioMed Central
SN  - 14712180
KW  - Escherichia coli
KW  - Colicin
KW  - Microcin
KW  - Bacteriocin
KW  - Virulence factor
UR  - https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-14-109
N2  - Background: A set of 1181 E. coli strains of human fecal origin isolated in the South Moravia region of the Czech Republic was collected during the years 2007-2010. Altogether, 17 virulence determinants and 31 bacteriocin-encoding genes were tested in each of them. Results: The occurrence of bacteriocin-encoding genes was found to be positively correlated with the occurrence of E. coli virulence factors. Based on the presence of virulence factors and their combinations, E. coli strains were classified as non-pathogenic E. coli (n = 399), diarrhea-associated E. coli (n = 179) and ExPEC strains (n = 603). Non-pathogenic and diarrhea-associated E. coli strains had a low frequency of bacteriocinogeny (32.6% and 36.9%, respectively). ExPEC strains encoding S-fimbriae (sfa), P-fimbriae (pap) and having genes for aerobactin biosynthesis (aer, iucC), alpha-hemolysis (alpha-hly) and cytotoxic necrosis factor (cnf1) were often bacteriocinogenic (73.8%), had a high prevalence of bacteriocin multi-producers and showed a higher frequency of genes encoding microcins H47, M, V, B17 and colicins E1, Ia and S4. Conclusions: The occurrence of bacteriocin-encoding genes and ExPEC virulence determinants correlate positively in E. coli strains of human fecal origin. Bacteriocin synthesis appears to modulate the ability of E. coli strains to reside in the human intestine and/or the virulence of the corresponding strains.
ER  -

MICENKOVÁ, Lenka; Barbora ŠTAUDOVÁ; Juraj BOSÁK; Lenka MIKALOVÁ; Simona LITTNEROVÁ; Martin VRBA; Alena ŠEVČÍKOVÁ; Vladana WOZNICOVÁ a David ŠMAJS. Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains. \textit{BMC Microbiology}. LONDON: BioMed Central, 2014, roč.~14, č.~109, s.~1-9. ISSN~1471-2180. Dostupné z: https://doi.org/10.1186/1471-2180-14-109.

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