Detailed Information on Publication Record
2014
Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains
MICENKOVÁ, Lenka, Barbora ŠTAUDOVÁ, Juraj BOSÁK, Lenka MIKALOVÁ, Simona LITTNEROVÁ et. al.Basic information
Original name
Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains
Authors
MICENKOVÁ, Lenka (703 Slovakia, belonging to the institution), Barbora ŠTAUDOVÁ (203 Czech Republic, belonging to the institution), Juraj BOSÁK (703 Slovakia, belonging to the institution), Lenka MIKALOVÁ (203 Czech Republic, belonging to the institution), Simona LITTNEROVÁ (203 Czech Republic, belonging to the institution), Martin VRBA (203 Czech Republic), Alena ŠEVČÍKOVÁ (203 Czech Republic), Vladana WOZNICOVÁ (203 Czech Republic, belonging to the institution) and David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution)
Edition
BMC Microbiology, LONDON, BioMed Central, 2014, 1471-2180
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10600 1.6 Biological sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.729
RIV identification code
RIV/00216224:14110/14:00080149
Organization unit
Faculty of Medicine
UT WoS
000335416800002
Keywords in English
Escherichia coli; Colicin; Microcin; Bacteriocin; Virulence factor
Tags
Tags
International impact, Reviewed
Změněno: 11/11/2014 10:39, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Background: A set of 1181 E. coli strains of human fecal origin isolated in the South Moravia region of the Czech Republic was collected during the years 2007-2010. Altogether, 17 virulence determinants and 31 bacteriocin-encoding genes were tested in each of them. Results: The occurrence of bacteriocin-encoding genes was found to be positively correlated with the occurrence of E. coli virulence factors. Based on the presence of virulence factors and their combinations, E. coli strains were classified as non-pathogenic E. coli (n = 399), diarrhea-associated E. coli (n = 179) and ExPEC strains (n = 603). Non-pathogenic and diarrhea-associated E. coli strains had a low frequency of bacteriocinogeny (32.6% and 36.9%, respectively). ExPEC strains encoding S-fimbriae (sfa), P-fimbriae (pap) and having genes for aerobactin biosynthesis (aer, iucC), alpha-hemolysis (alpha-hly) and cytotoxic necrosis factor (cnf1) were often bacteriocinogenic (73.8%), had a high prevalence of bacteriocin multi-producers and showed a higher frequency of genes encoding microcins H47, M, V, B17 and colicins E1, Ia and S4. Conclusions: The occurrence of bacteriocin-encoding genes and ExPEC virulence determinants correlate positively in E. coli strains of human fecal origin. Bacteriocin synthesis appears to modulate the ability of E. coli strains to reside in the human intestine and/or the virulence of the corresponding strains.
Links
| NT13413, research and development project |
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