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@article{1205812, author = {Nehybová, Tereza and Šmarda, Jan and Beneš, Petr}, article_number = {10}, doi = {http://dx.doi.org/10.2174/1871520614666140713172949}, keywords = {cancer; cellular target; coumestrol; coumestan; glycyrol; psoralidin; therapy; wedelolactone}, language = {eng}, issn = {1871-5206}, journal = {Anti-Cancer Agents in Medicinal Chemistry}, title = {Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy}, volume = {14}, year = {2014} }
TY - JOUR ID - 1205812 AU - Nehybová, Tereza - Šmarda, Jan - Beneš, Petr PY - 2014 TI - Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy JF - Anti-Cancer Agents in Medicinal Chemistry VL - 14 IS - 10 SP - 1351-1362 EP - 1351-1362 PB - Bentham Science Publishers SN - 18715206 KW - cancer KW - cellular target KW - coumestrol KW - coumestan KW - glycyrol KW - psoralidin KW - therapy KW - wedelolactone N2 - Natural products are often used in drug development due to their ability to form unique and diverse chemical structures. Coumestans are polycyclic aromatic plant secondary metabolites containing a coumestan moiety, which consists of a benzoxole fused to a chromen-2-one to form 1-Benzoxolo[3,2-c]chromen-6-one. These natural compounds are known for large number of biological activities. Many of their biological effects can be attributed to their action as phytoestrogens and polyphenols. In the last decade, anticancer effects of these compounds have been described in vitro but there is only limited number of studies based on models in vivo. More information concerning their in vivo bioavailability, stability, metabolism, toxicity, estrogenicity, cellular targets and drug interactions is therefore needed to proceed further to clinical studies. This review focuses on coumestans exhibiting anticancer properties and summarizes mechanisms of their toxicity to cancer cells. Moreover, the possible role of coumestans in cancer prevention is discussed. ER -
NEHYBOVÁ, Tereza, Jan ŠMARDA and Petr BENEŠ. Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy. \textit{Anti-Cancer Agents in Medicinal Chemistry}. Bentham Science Publishers, 2014, vol.~14, No~10, p.~1351-1362. ISSN~1871-5206. Available from: https://dx.doi.org/10.2174/1871520614666140713172949.
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