Lack of adenosine A(3) receptors causes defects in mouse
peripheral blood parameters

J 2014

Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

HOFER, Michal, Milan POSPÍŠIL, Ladislav DUŠEK, Zuzana HOFEROVÁ, Denisa KOMŮRKOVÁ et. al.

Basic information

Original name

Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

Authors

HOFER, Michal (203 Czech Republic), Milan POSPÍŠIL (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, guarantor, belonging to the institution), Zuzana HOFEROVÁ (203 Czech Republic) and Denisa KOMŮRKOVÁ (203 Czech Republic)

Edition

Purinergic signalling, Dordrecht, Springer, 2014, 1573-9538

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.886

RIV identification code

RIV/00216224:14110/14:00077295

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s11302-014-9412-9

UT WoS

000341772500010

Keywords in English

Adenosine A(3) receptor; Adenosine A(3) receptor knockout mice; Hematopoiesis; Whole-body irradiation

Abstract

V originále

The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO mice and WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic system. Statistically significantly increased values of the bone marrow parameters studied in A(3)AR KO mice (femoral bone marrow cellularity, granulocyte/macrophage progenitor cells, and erythrocyte progenitor cells) can probably be explained by compensatory mechanisms attempting to offset the disorders in the function of blood elements in these mice. The pattern of the radiation-induced hematopoietic suppression was very similar in A(3)AR KO mice and their WT counterparts.

Citovat

HOFER, Michal, Milan POSPÍŠIL, Ladislav DUŠEK, Zuzana HOFEROVÁ and Denisa KOMŮRKOVÁ. Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters. Purinergic signalling. Dordrecht: Springer, 2014, vol. 10, No 3, p. 509-514. ISSN 1573-9538. Available from: https://dx.doi.org/10.1007/s11302-014-9412-9.

@article{1205837,
   author = {Hofer, Michal and Pospíšil, Milan and Dušek, Ladislav and Hoferová, Zuzana and Komůrková, Denisa},
   article_location = {Dordrecht},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s11302-014-9412-9},
   keywords = {Adenosine A(3) receptor; Adenosine A(3) receptor knockout mice; Hematopoiesis; Whole-body irradiation},
   language = {eng},
   issn = {1573-9538},
   journal = {Purinergic signalling},
   title = {Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters},
   volume = {10},
   year = {2014}
}

TY  - JOUR
ID  - 1205837
AU  - Hofer, Michal - Pospíšil, Milan - Dušek, Ladislav - Hoferová, Zuzana - Komůrková, Denisa
PY  - 2014
TI  - Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters
JF  - Purinergic signalling
VL  - 10
IS  - 3
SP  - 509-514
EP  - 509-514
PB  - Springer
SN  - 15739538
KW  - Adenosine A(3) receptor
KW  - Adenosine A(3) receptor knockout mice
KW  - Hematopoiesis
KW  - Whole-body irradiation
N2  - The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO mice and WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic system. Statistically significantly increased values of the bone marrow parameters studied in A(3)AR KO mice (femoral bone marrow cellularity, granulocyte/macrophage progenitor cells, and erythrocyte progenitor cells) can probably be explained by compensatory mechanisms attempting to offset the disorders in the function of blood elements in these mice. The pattern of the radiation-induced hematopoietic suppression was very similar in A(3)AR KO mice and their WT counterparts.
ER  -

HOFER, Michal, Milan POSPÍŠIL, Ladislav DUŠEK, Zuzana HOFEROVÁ and Denisa KOMŮRKOVÁ. Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters. \textit{Purinergic signalling}. Dordrecht: Springer, 2014, vol.~10, No~3, p.~509-514. ISSN~1573-9538. Available from: https://dx.doi.org/10.1007/s11302-014-9412-9.

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