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@inbook{1206177,
author = {Mlčochová, Hana and Héžová, Renata and Meli, Albano and Slabý, Ondřej},
address = {USA},
booktitle = {RNA Interference},
doi = {http://dx.doi.org/10.1007/978-1-4939-1538-5_26},
editor = {Sioud, Mouldy},
keywords = {microRNA; Diagnosis; Prognosis; Biomarker; Urologic cancer; Urothelial cancer; Bladder cancer; Prostate cancer; Renal cell carcinoma; Myocardial infarction; Cardiomyopathy; Heart failure},
howpublished = {tištěná verze "print"},
language = {eng},
location = {USA},
isbn = {978-1-4939-1537-8},
pages = {439-463},
publisher = {Springer New York},
title = {Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology},
year = {2015}
}
TY - CHAP
ID - 1206177
AU - Mlčochová, Hana - Héžová, Renata - Meli, Albano - Slabý, Ondřej
PY - 2015
TI - Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology
VL - Methods in Molecular Biology, 1218
PB - Springer New York
CY - USA
SN - 9781493915378
KW - microRNA
KW - Diagnosis
KW - Prognosis
KW - Biomarker
KW - Urologic cancer
KW - Urothelial cancer
KW - Bladder cancer
KW - Prostate cancer
KW - Renal cell carcinoma
KW - Myocardial infarction
KW - Cardiomyopathy
KW - Heart failure
N2 - MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. In the last decade, number of evidences showing miRNAs contribution to the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes is constantly growing. Specific miRNA expression signatures have been identified in variety of human cancers as well as pathologies of cardiovascular and urinary systems. Our chapter focuses on the potential of urinary miRNAs to serve as biomarkers in uro-oncology, nephrology, and cardiology. We discuss in detail recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in medicine. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in urologic cancers, nephrology, and cardiology.
ER -
MLČOCHOVÁ, Hana, Renata HÉŽOVÁ, Albano MELI and Ondřej SLABÝ. Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology. In Sioud, Mouldy. \textit{RNA Interference}. USA: Springer New York, 2015, p.~439-463. Methods in Molecular Biology, 1218. ISBN~978-1-4939-1537-8. Available from: https://dx.doi.org/10.1007/978-1-4939-1538-5\_{}26.
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