Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in
Oncology, Nephrology, and Cardiology

C 2015

Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology

MLČOCHOVÁ, Hana, Renata HÉŽOVÁ, Albano MELI and Ondřej SLABÝ

Basic information

Original name

Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology

Authors

MLČOCHOVÁ, Hana (203 Czech Republic, belonging to the institution), Renata HÉŽOVÁ (203 Czech Republic, belonging to the institution), Albano MELI (250 France, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

USA, RNA Interference, p. 439-463, 25 pp. Methods in Molecular Biology, 1218, 2015

Publisher

Springer New York

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

RIV identification code

RIV/00216224:14740/15:00082166

Organization unit

Central European Institute of Technology

ISBN

978-1-4939-1537-8

DOI

http://dx.doi.org/10.1007/978-1-4939-1538-5_26

UT WoS

000343463900027

Keywords in English

microRNA; Diagnosis; Prognosis; Biomarker; Urologic cancer; Urothelial cancer; Bladder cancer; Prostate cancer; Renal cell carcinoma; Myocardial infarction; Cardiomyopathy; Heart failure

Abstract

V originále

MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. In the last decade, number of evidences showing miRNAs contribution to the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes is constantly growing. Specific miRNA expression signatures have been identified in variety of human cancers as well as pathologies of cardiovascular and urinary systems. Our chapter focuses on the potential of urinary miRNAs to serve as biomarkers in uro-oncology, nephrology, and cardiology. We discuss in detail recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in medicine. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in urologic cancers, nephrology, and cardiology.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

NT13547, research and development project

Name: Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem

Citovat

MLČOCHOVÁ, Hana, Renata HÉŽOVÁ, Albano MELI and Ondřej SLABÝ. Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology. In Sioud, Mouldy. RNA Interference. USA: Springer New York, 2015, p. 439-463. Methods in Molecular Biology, 1218. ISBN 978-1-4939-1537-8. Available from: https://dx.doi.org/10.1007/978-1-4939-1538-5_26.

@inbook{1206177,
   author = {Mlčochová, Hana and Héžová, Renata and Meli, Albano and Slabý, Ondřej},
   address = {USA},
   booktitle = {RNA Interference},
   doi = {http://dx.doi.org/10.1007/978-1-4939-1538-5_26},
   editor = {Sioud, Mouldy},
   keywords = {microRNA; Diagnosis; Prognosis; Biomarker; Urologic cancer; Urothelial cancer; Bladder cancer; Prostate cancer; Renal cell carcinoma; Myocardial infarction; Cardiomyopathy; Heart failure},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {USA},
   isbn = {978-1-4939-1537-8},
   pages = {439-463},
   publisher = {Springer New York},
   title = {Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology},
   year = {2015}
}

TY  - CHAP
ID  - 1206177
AU  - Mlčochová, Hana - Héžová, Renata - Meli, Albano - Slabý, Ondřej
PY  - 2015
TI  - Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology
VL  - Methods in Molecular Biology, 1218
PB  - Springer New York
CY  - USA
SN  - 9781493915378
KW  - microRNA
KW  - Diagnosis
KW  - Prognosis
KW  - Biomarker
KW  - Urologic cancer
KW  - Urothelial cancer
KW  - Bladder cancer
KW  - Prostate cancer
KW  - Renal cell carcinoma
KW  - Myocardial infarction
KW  - Cardiomyopathy
KW  - Heart failure
N2  - MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. In the last decade, number of evidences showing miRNAs contribution to the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes is constantly growing. Specific miRNA expression signatures have been identified in variety of human cancers as well as pathologies of cardiovascular and urinary systems. Our chapter focuses on the potential of urinary miRNAs to serve as biomarkers in uro-oncology, nephrology, and cardiology. We discuss in detail recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in medicine. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in urologic cancers, nephrology, and cardiology.
ER  -

MLČOCHOVÁ, Hana, Renata HÉŽOVÁ, Albano MELI and Ondřej SLABÝ. Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology. In Sioud, Mouldy. \textit{RNA Interference}. USA: Springer New York, 2015, p.~439-463. Methods in Molecular Biology, 1218. ISBN~978-1-4939-1537-8. Available from: https://dx.doi.org/10.1007/978-1-4939-1538-5\_{}26.

Detailed Information on Publication Record